Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus.
Adolescent
Age of Onset
Autoantibodies
/ immunology
Biomarkers
/ blood
Ceruloplasmin
Chemokine CCL2
Child
Child, Preschool
Female
Humans
Intramolecular Oxidoreductases
Kidney
/ pathology
Lipocalin-2
Lipocalins
Lupus Erythematosus, Systemic
/ metabolism
Male
Orosomucoid
Phenotype
Severity of Illness Index
Transferrin
arthritis biomarkers
cardiovascular biomarkers
genetic biomarkers
haematological biomarkers
juvenile systemic lupus erythematosus
neurological biomarkers
organ-specific biomarkers
renal biomarkers
skin disease biomarkers
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
17
05
2021
revised:
24
06
2021
accepted:
25
06
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
13
8
2021
Statut:
epublish
Résumé
Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.
Identifiants
pubmed: 34299237
pii: ijms22147619
doi: 10.3390/ijms22147619
pmc: PMC8306911
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Chemokine CCL2
0
Lipocalin-2
0
Lipocalins
0
Orosomucoid
0
Transferrin
0
Ceruloplasmin
EC 1.16.3.1
Intramolecular Oxidoreductases
EC 5.3.-
prostaglandin R2 D-isomerase
EC 5.3.99.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Versus Arthritis
ID : 21593
Pays : United Kingdom
Organisme : UCLH Biomedical Research Centre
ID : III/CC/191350
Organisme : UCLH Biomedical Research Centre
ID : BRC 773/III/CC/101350
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