Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells.
Animals
Arginase
/ genetics
Biomarkers
Bone Marrow Cells
/ metabolism
CD4-Positive T-Lymphocytes
/ immunology
Cell Line, Tumor
Computational Biology
/ methods
Disease Models, Animal
Disease Susceptibility
Gene Expression Profiling
Humans
Mice
Mice, Transgenic
Myeloid Cells
/ metabolism
Neuroblastoma
/ etiology
Oncogenes
Single-Cell Analysis
Transcriptome
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
02
03
2021
revised:
29
05
2021
accepted:
22
07
2021
pubmed:
25
7
2021
medline:
4
1
2022
entrez:
24
7
2021
Statut:
ppublish
Résumé
Immune cells regulate tumor growth by mirroring their function as tissue repair organizers in normal tissues. To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunologic manipulation with noninvasive, longitudinal imaging, we generated a penetrant double oncogene-driven autochthonous model of neuroblastoma. Spatial transcriptomic analysis showed that CD4
Identifiants
pubmed: 34301764
pii: 0008-5472.CAN-21-0691
doi: 10.1158/0008-5472.CAN-21-0691
pmc: PMC8488023
mid: NIHMS1729425
doi:
Substances chimiques
Biomarkers
0
ARG1 protein, human
EC 3.5.3.1
Arginase
EC 3.5.3.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5047-5059Subventions
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121832
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA189990
Pays : United States
Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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