An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
calcification
cell physiology
intracellular pH
ocean acidification
sea urchin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and statoconia in vertebrates but whose underlying cellular mechanisms remain largely unknown. Here, we demonstrate that otopetrins are critically involved in the calcification process by providing an exit route for protons liberated by the formation of CaCO
Identifiants
pubmed: 34301868
pii: 2101378118
doi: 10.1073/pnas.2101378118
pmc: PMC8325241
pii:
doi:
Substances chimiques
Ion Channels
0
Protons
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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