Thomas Baukrowitz

Affiliations

Institute of Physiology, Kiel University, Kiel, Germany.

ORCID: 0000-0003-4562-0505

Publications (11)

The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism.

The Journal of general physiology

Avec: Elena B Riel , Björn C Jürs , Sönke Cordeiro , Marianne Musinszki , Marcus Schewe , Thomas Baukrowitz

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K

The Journal of biological chemistry

Avec: Ehsan Nematian-Ardestani , Firdaus Abd-Wahab , Franck C Chatelain , Han Sun , Marcus Schewe , Thomas Baukrowitz , Stephen J Tucker

The molecular basis for an allosteric inhibition of K

eLife

Avec: Susanne Rinné , Aytug K Kiper , Kirsty S Vowinkel , David Ramírez , Marcus Schewe , Mauricio Bedoya , Diana Aser , Isabella Gensler , Michael F Netter , Phillip J Stansfeld , Thomas Baukrowitz , Wendy Gonzalez , Niels Decher

A pharmacological master key mechanism that unlocks the selectivity filter gate in K

Science (New York, N.Y.)

Avec: Marcus Schewe , Han Sun , Ümit Mert , Alexandra Mackenzie , Ashley C W Pike , Friederike Schulz , Cristina Constantin , Kirsty S Vowinkel , Linus J Conrad , Aytug K Kiper , Wendy Gonzalez , Marianne Musinszki , Marie Tegtmeier , David C Pryde , Hassane Belabed , Marc Nazare , Bert L de Groot , Niels Decher , Bernd Fakler , Elisabeth P Carpenter , Stephen J Tucker , Thomas Baukrowitz

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.

Nature communications

Avec: Karin E J Rödström , Alexander Cloake , Janina Sörmann , Agnese Baronina , Kathryn H M Smith , Ashley C W Pike , Jackie Ang , Peter Proks , Marcus Schewe , Ingelise Holland-Kaye , Simon R Bushell , Jenna Elliott , Els Pardon , Thomas Baukrowitz , Raymond J Owens , Simon Newstead , Jan Steyaert , Elisabeth P Carpenter , Stephen J Tucker

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.

Nature genetics

Avec: Janina Sörmann , Marcus Schewe , Peter Proks , Thibault Jouen-Tachoire , Shanlin Rao , Elena B Riel , Katherine E Agre , Amber Begtrup , John Dean , Maria Descartes , Jan Fischer , Alice Gardham , Carrie Lahner , Paul R Mark , Srikanth Muppidi , Pavel N Pichurin , Joseph Porrmann , Jens Schallner , Kirstin Smith , Volker Straub , Pradeep Vasudevan , Rebecca Willaert , Elisabeth P Carpenter , Karin E J Rödström , Michael G Hahn , Thomas Müller , Thomas Baukrowitz , Matthew E Hurles , Caroline F Wright , Stephen J Tucker

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.

The Journal of general physiology

Avec: Peter Proks , Marcus Schewe , Linus J Conrad , Shanlin Rao , Kristin Rathje , Karin E J Rödström , Elisabeth P Carpenter , Thomas Baukrowitz , Stephen J Tucker

An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.

Proceedings of the National Academy of Sciences of the United States of America

Avec: William W Chang , Ann-Sophie Matt , Marcus Schewe , Marianne Musinszki , Sandra Grüssel , Jonas Brandenburg , David Garfield , Markus Bleich , Thomas Baukrowitz , Marian Y Hu

Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation.

Biological chemistry

Avec: Christina B Schroeter , Christopher Nelke , Marcus Schewe , Lucas Spohler , Alexander M Herrmann , Thomas Müntefering , Niklas Huntemann , Maria Kuzikov , Philip Gribbon , Sarah Albrecht , Stefanie Bock , Petra Hundehege , Lea Christine Neelsen , Thomas Baukrowitz , Guiscard Seebohm , Bernhard Wünsch , Stefan Bittner , Tobias Ruck , Thomas Budde , Sven G Meuth

Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels.

Nature communications

Avec: Berke Türkaydin , Marcus Schewe , Elena Barbara Riel , Friederike Schulz , Johann Biedermann , Thomas Baukrowitz , Han Sun

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K

Nature communications

Avec: Lea C Neelsen , Elena B Riel , Susanne Rinné , Freya-Rebecca Schmid , Björn C Jürs , Mauricio Bedoya , Jan P Langer , Bisher Eymsh , Aytug K Kiper , Sönke Cordeiro , Niels Decher , Thomas Baukrowitz , Marcus Schewe

Réseau de co-auteurs

Marcus Schewe 11 collaborations

Stephen J Tucker 5 collaborations

Elisabeth P Carpenter 4 collaborations

Elena B Riel 3 collaborations

Marianne Musinszki 3 collaborations

Han Sun 3 collaborations

Aytug K Kiper 3 collaborations

Niels Decher 3 collaborations

Karin E J Rödström 3 collaborations

Peter Proks 3 collaborations

Björn C Jürs 2 collaborations

Sönke Cordeiro 2 collaborations

Susanne Rinné 2 collaborations

Kirsty S Vowinkel 2 collaborations

Mauricio Bedoya 2 collaborations

Wendy Gonzalez 2 collaborations

Ashley C W Pike 2 collaborations

Friederike Schulz 2 collaborations

Linus J Conrad 2 collaborations

Janina Sörmann 2 collaborations

Shanlin Rao 2 collaborations

Ehsan Nematian-Ardestani 1 collaboration

Firdaus Abd-Wahab 1 collaboration

Franck C Chatelain 1 collaboration

David Ramírez 1 collaboration

Diana Aser 1 collaboration

Isabella Gensler 1 collaboration

Michael F Netter 1 collaboration

Phillip J Stansfeld 1 collaboration

Ümit Mert 1 collaboration

Alexandra Mackenzie 1 collaboration

Cristina Constantin 1 collaboration

Marie Tegtmeier 1 collaboration

David C Pryde 1 collaboration

Hassane Belabed 1 collaboration

Marc Nazare 1 collaboration

Bert L de Groot 1 collaboration

Bernd Fakler 1 collaboration

Alexander Cloake 1 collaboration

Agnese Baronina 1 collaboration

Kathryn H M Smith 1 collaboration

Jackie Ang 1 collaboration

Ingelise Holland-Kaye 1 collaboration

Simon R Bushell 1 collaboration

Jenna Elliott 1 collaboration

Els Pardon 1 collaboration

Raymond J Owens 1 collaboration

Simon Newstead 1 collaboration

Jan Steyaert 1 collaboration

Thibault Jouen-Tachoire 1 collaboration

Katherine E Agre 1 collaboration

Amber Begtrup 1 collaboration

John Dean 1 collaboration

Maria Descartes 1 collaboration

Jan Fischer 1 collaboration

Alice Gardham 1 collaboration

Carrie Lahner 1 collaboration

Paul R Mark 1 collaboration

Srikanth Muppidi 1 collaboration

Pavel N Pichurin 1 collaboration

Joseph Porrmann 1 collaboration

Jens Schallner 1 collaboration

Kirstin Smith 1 collaboration

Volker Straub 1 collaboration

Pradeep Vasudevan 1 collaboration

Rebecca Willaert 1 collaboration

Michael G Hahn 1 collaboration

Thomas Müller 1 collaboration

Matthew E Hurles 1 collaboration

Caroline F Wright 1 collaboration

Kristin Rathje 1 collaboration

William W Chang 1 collaboration

Ann-Sophie Matt 1 collaboration

Sandra Grüssel 1 collaboration

Jonas Brandenburg 1 collaboration

David Garfield 1 collaboration

Markus Bleich 1 collaboration

Marian Y Hu 1 collaboration

Christina B Schroeter 1 collaboration

Christopher Nelke 1 collaboration

Lucas Spohler 1 collaboration

Alexander M Herrmann 1 collaboration

Thomas Müntefering 1 collaboration

Niklas Huntemann 1 collaboration

Maria Kuzikov 1 collaboration

Philip Gribbon 1 collaboration

Sarah Albrecht 1 collaboration

Stefanie Bock 1 collaboration

Petra Hundehege 1 collaboration

Lea Christine Neelsen 1 collaboration

Guiscard Seebohm 1 collaboration

Bernhard Wünsch 1 collaboration

Stefan Bittner 1 collaboration

Tobias Ruck 1 collaboration

Thomas Budde 1 collaboration

Sven G Meuth 1 collaboration

Berke Türkaydin 1 collaboration

Elena Barbara Riel 1 collaboration

Johann Biedermann 1 collaboration

Lea C Neelsen 1 collaboration

Freya-Rebecca Schmid 1 collaboration

Jan P Langer 1 collaboration

Bisher Eymsh 1 collaboration