Hematopathologic Correlates of CAR T-Cell Therapy.

Antigens, CD19 Humans Immunotherapy, Adoptive Precursor Cell Lymphoblastic Leukemia-Lymphoma Receptors, Antigen, T-Cell T-Lymphocytes
B-ALL CAR T-cell therapy CD19 Hematopathology Immunotherapy Tisagenlecleucel

Journal

Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174

Informations de publication

Date de publication:
09 2021
Historique:
entrez: 26 7 2021
pubmed: 27 7 2021
medline: 26 10 2021
Statut: ppublish

Résumé

CD19-targeting chimeric antigen rector (CAR) T-cell products are used for the treatment of relapsed/refractory B-acute lymphoblastic leukemia, diffuse large B-cell lymphoma, and mantle cell lymphoma. The success of CD19-CAR-T cells has led to the investigation of CAR T-cell products targeting different antigens in other hematological malignancies and solid tumors. Clinical laboratories play an important role in the manufacture, distribution, and monitoring of CAR T-cell therapy. Hence, it is important for laboratory professionals to be cognizant of clinicopathologic aspects of CAR T-cell therapy.

Identifiants

DOI: 10.1016/j.cll.2021.03.012 PMID: 34304768
pubmed: 34304768
pii: S0272-2712(21)00012-3
doi: 10.1016/j.cll.2021.03.012
pii:
doi:

Substances chimiques

Antigens, CD19 0
Receptors, Antigen, T-Cell 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

325-339

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

J Gregory Dolan (JG)

Division of Oncology and Cellular Therapy, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Michele E Paessler (ME)

Division of Hematopathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Susan R Rheingold (SR)

Division of Oncology and Cellular Therapy, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Vinodh Pillai (V)

Division of Hematopathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: pillaiv1@chop.edu.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes B › Antigènes CD19 › Hematopathologic Correlates of CAR T-Cell Therapy.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hematopathologic Correlates of CAR T-Cell Therapy.
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Hematopathologic Correlates of CAR T-Cell Therapy.
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Hematopathologic Correlates of CAR T-Cell Therapy.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Hematopathologic Correlates of CAR T-Cell Therapy.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Hematopathologic Correlates of CAR T-Cell Therapy.