Hydroxyphenyl Butanone Induces Cell Cycle Arrest through Inhibition of GSK3
Butanones
/ pharmacology
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Colorectal Neoplasms
/ enzymology
G1 Phase
/ drug effects
Glycogen Synthase Kinase 3 beta
/ antagonists & inhibitors
Humans
Neoplasm Invasiveness
Plant Extracts
/ pharmacology
Rubus
/ chemistry
S Phase
/ drug effects
Tumor Stem Cell Assay
Wnt Signaling Pathway
/ drug effects
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
04
2021
revised:
30
04
2021
accepted:
15
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
23
9
2021
Statut:
epublish
Résumé
Colorectal cancer (CRC) is among the top three gastrointestinal malignancy in morbidity and mortality. The abnormal activation of Wnt/ Cell proliferation was detected after hydroxyphenyl butanone treatment in human colorectal cancer HCT116, LOVO, and normal colonic epithelial NCM460 cells. Colony formation, cell invasion ability, and cell cycle were detected with and without GSK-3 Hydroxyphenyl butanone induces cycle arresting on G1-S phase of colorectal cancer cell line through GSK3 This study illustrated natural hydroxyphenyl butanone as new inhibitor of GSK3
Sections du résumé
BACKGROUND
BACKGROUND
Colorectal cancer (CRC) is among the top three gastrointestinal malignancy in morbidity and mortality. The abnormal activation of Wnt/
METHODS
METHODS
Cell proliferation was detected after hydroxyphenyl butanone treatment in human colorectal cancer HCT116, LOVO, and normal colonic epithelial NCM460 cells. Colony formation, cell invasion ability, and cell cycle were detected with and without GSK-3
RESULTS
RESULTS
Hydroxyphenyl butanone induces cycle arresting on G1-S phase of colorectal cancer cell line through GSK3
CONCLUSION
CONCLUSIONS
This study illustrated natural hydroxyphenyl butanone as new inhibitor of GSK3
Identifiants
pubmed: 34307685
doi: 10.1155/2021/9981815
pmc: PMC8272657
doi:
Substances chimiques
Butanones
0
Plant Extracts
0
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9981815Informations de copyright
Copyright © 2021 Songyan Zhang et al.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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