Contralateral Suppression of Spontaneous Otoacoustic Emissions in Individuals With Auditory Neuropathy Spectrum Disorder.
Journal
The journal of international advanced otology
ISSN: 2148-3817
Titre abrégé: J Int Adv Otol
Pays: Turkey
ID NLM: 101522982
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
28
9
2021
Statut:
ppublish
Résumé
The current study attempted to assess efferent auditory system functioning in individuals with auditory neuropathy spectrum disorder (ANSD) using a new approach, contralateral suppression of SOAE, which has not yet been extensively researched. Spontaneous otoacoustic emissions (SOAEs) were recorded in a total of 62 ears, divided into 2 groups. Group I comprised of 31 ears with normal hearing (NH), while group II consisted of 31 ears with ANSD. All the participants considered for the study were in the age range of 18-45 years. Synchronized SOAE were recorded using the ILO V6 OAE instrument with and without noise (broadband noise, 50 dB SPL) in the contralateral ear. The frequency and amplitude shifts secondary to the introduction of contralateral noise were analyzed. The results of the study showed a statistically significant high-frequency shift of SOAE with contralateral noise for the NH and ANSD groups. In addition, the NH group also exhibited a statistically significant reduction in SOAE amplitude in contralateral noise conditions. Such a reduction in SOAE amplitude was not observed in individuals with ANSD. The absence of suppression of SOAE amplitude suggests efferent damage in individuals with ANSD. The shift in SOAE frequency toward higher frequency in the ANSD group, which is similar to NH group, is suggestive of differential allotment of medial olivocochlear (MOC) mechanism in individuals with ANSD, which codes for contralateral frequency changes and not for amplitude changes.
Sections du résumé
BACKGROUND
BACKGROUND
The current study attempted to assess efferent auditory system functioning in individuals with auditory neuropathy spectrum disorder (ANSD) using a new approach, contralateral suppression of SOAE, which has not yet been extensively researched.
METHODS
METHODS
Spontaneous otoacoustic emissions (SOAEs) were recorded in a total of 62 ears, divided into 2 groups. Group I comprised of 31 ears with normal hearing (NH), while group II consisted of 31 ears with ANSD. All the participants considered for the study were in the age range of 18-45 years. Synchronized SOAE were recorded using the ILO V6 OAE instrument with and without noise (broadband noise, 50 dB SPL) in the contralateral ear. The frequency and amplitude shifts secondary to the introduction of contralateral noise were analyzed.
RESULTS
RESULTS
The results of the study showed a statistically significant high-frequency shift of SOAE with contralateral noise for the NH and ANSD groups. In addition, the NH group also exhibited a statistically significant reduction in SOAE amplitude in contralateral noise conditions. Such a reduction in SOAE amplitude was not observed in individuals with ANSD.
CONCLUSION
CONCLUSIONS
The absence of suppression of SOAE amplitude suggests efferent damage in individuals with ANSD. The shift in SOAE frequency toward higher frequency in the ANSD group, which is similar to NH group, is suggestive of differential allotment of medial olivocochlear (MOC) mechanism in individuals with ANSD, which codes for contralateral frequency changes and not for amplitude changes.
Identifiants
pubmed: 34309553
doi: 10.5152/iao.2021.9098
pmc: PMC8975389
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-329Références
J Neurophysiol. 1991 Mar;65(3):724-35
pubmed: 2051201
Br J Audiol. 1994 Aug-Oct;28(4-5):213-8
pubmed: 7735149
J Am Acad Audiol. 2003 Aug;14(6):302-13
pubmed: 14552424
J Assoc Res Otolaryngol. 2010 Mar;11(1):53-67
pubmed: 19798532
Arch Otolaryngol Head Neck Surg. 2001 Jun;127(6):629-36
pubmed: 11405860
J Acoust Soc Am. 1991 May;89(5):2027-67
pubmed: 1860995
Brain. 1996 Jun;119 ( Pt 3):741-53
pubmed: 8673487
J Neurosci. 1996 Jan;16(1):325-32
pubmed: 8613799
J Acoust Soc Am. 1996 Jun;99(6):3572-84
pubmed: 8655789
J Physiol. 2003 Apr 1;548(Pt 1):307-12
pubmed: 12611913
Hear Res. 1989 Apr;38(3):229-42
pubmed: 2708165
J Acoust Soc Am. 2003 Jul;114(1):244-62
pubmed: 12880039
Ear Hear. 2000 Dec;21(6):542-53
pubmed: 11132781
J Assoc Res Otolaryngol. 2003 Dec;4(4):521-40
pubmed: 12799992
Ear Hear. 1999 Jun;20(3):238-52
pubmed: 10386850
J Basic Clin Physiol Pharmacol. 2000;11(3):215-30
pubmed: 11041385