Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast.
Carbocyanines
/ pharmacology
Cell Cycle
/ genetics
Cell Division
/ genetics
Cell Proliferation
/ genetics
DNA Polymerase III
/ genetics
Gene Expression Regulation, Fungal
/ drug effects
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ genetics
Mitochondrial Dynamics
/ genetics
Oxygen Consumption
/ drug effects
Saccharomyces cerevisiae
/ genetics
Saccharomyces cerevisiae Proteins
/ genetics
cell cycle
dnm1
fzo1
mitochondria
mitochondrial dynamics
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
15
07
2021
received:
02
03
2021
accepted:
22
07
2021
pubmed:
27
7
2021
medline:
26
2
2022
entrez:
26
7
2021
Statut:
ppublish
Résumé
Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood. Here, we dissected the roles of mitochondrial fusion and fission in mitochondrial function and cell proliferation in fission yeast. We examined mitochondrial membrane potential by staining cells with DiOC
Substances chimiques
Carbocyanines
0
POL3 protein, S cerevisiae
0
Saccharomyces cerevisiae Proteins
0
3,3'-dihexyl-2,2'-oxacarbocyanine
54501-79-0
DNA Polymerase III
EC 2.7.7.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-278Informations de copyright
© 2021 Federation of European Biochemical Societies.
Références
Liesa M & Shirihai OS (2013) Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab 17, 491-506.
Westermann B (2010) Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11, 872-884.
Giorgi C, Marchi S & Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19, 713-730.
Chan DC (2019) Mitochondrial dynamics and its involvement in disease. Annu Rev Pathol 15, 235-259.
Sesaki H & Jensen RE (1999) Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J Cell Biol 147, 699-706.
Sesaki H, Adachi Y, Kageyama Y, Itoh K & Iijima M (2014) In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta 1842, 1179-1185.
Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE & Chan DC (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160, 189-200.
Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV et al. (2011) The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell 22, 2235-2245.
Fenton AR, Jongens TA & Holzbaur ELF (2020) Mitochondrial dynamics: Shaping and remodeling an organelle network. Curr Opin Cell Biol 68, 28-36.
Bernhardt D, Muller M, Reichert AS & Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep 5, 7885.
Trevisan T, Pendin D, Montagna A, Bova S, Ghelli AM & Daga A (2018) Manipulation of mitochondria dynamics reveals separate roles for form and function in mitochondria distribution. Cell Rep 23, 1742-1753.
Fu C, Jain D, Costa J, Velve-Casquillas G & Tran PT (2011) mmb1p binds mitochondria to dynamic microtubules. Curr Biol 21, 1431-1439.
Das M, Chiron S & Verde F (2010) Microtubule-dependent spatial organization of mitochondria in fission yeast. Methods Cell Biol 97, 203-221.
Yang Y, Hu Y, Wu L, Zhang P & Shang J (2021) dnm1 deletion blocks mitochondrial fragmentation in Deltafzo1 cells. Yeast 38, 197-205.
Rapaport D, Brunner M, Neupert W & Westermann B (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273, 20150-20155.
Zheng F, Jia B, Dong F, Liu L, Rasul F, He J & Fu C (2019) Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast. J Biol Chem 294, 17725-17734.
Zhao D, Liu XM, Yu ZQ, Sun LL, Xiong X, Dong MQ & Du LL (2016) Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast. J Cell Sci 129, 4289-4304.
Valente AJ, Maddalena LA, Robb EL, Moradi F & Stuart JA (2017) A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture. Acta Histochem 119, 315-326.
Hori A, Yoshida M & Ling F (2011) Mitochondrial fusion increases the mitochondrial DNA copy number in budding yeast. Genes Cells 16, 527-544.
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM & Chan DC (2010) Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141, 280-289.
Rubio A, Garcia-Blanco N, Vazquez-Bolado A, Belen Suarez M & Moreno S (2018) Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription. J Cell Sci 131, 2817.
Benito J, Martin-Castellanos C & Moreno S (1998) Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor. EMBO J 17, 482-497.
Correa-Bordes J, Gulli MP & Nurse P (1997) p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle. EMBO J 16, 4657-4664.
Moreno S & Nurse P (1994) Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Nature 367, 236-242.
Yamano H, Kitamura K, Kominami K, Lehmann A, Katayama S, Hunt T & Toda T (2000) The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases. Mol Cell 6, 1377-1387.
Mondesert O, McGowan CH & Russell P (1996) Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol Cell Biol 16, 1527-1533.
Kageyama Y, Zhang Z, Roda R, Fukaya M, Wakabayashi J, Wakabayashi N, Kensler TW, Reddy PH, Iijima M & Sesaki H (2012) Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol 197, 535-551.
Zhang Z, Kageyama Y & Sesaki H (2012) Mitochondrial division prevents neurodegeneration. Autophagy 8, 1531-1533.
Hoffman CS, Wood V & Fantes PA (2015) An ancient yeast for young geneticists: a primer on the schizosaccharomyces pombe model system. Genetics 201, 403-423.
Meeusen SL & Nunnari J (2005) How mitochondria fuse. Curr Opin Cell Biol 17, 389-394.
Yuan R, Ding X, Tan X & Hou Y (2020) Loss of FZO1 gene results in changes of cell dynamics in fission yeast. Int J Mol Med 46, 2194-2206.
Mitra K (2013) Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation. BioEssays 35, 955-964.
Lee S, Park YY, Kim SH, Nguyen OT, Yoo YS, Chan GK, Sun X & Cho H (2014) Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition. Cell Mol Life Sci 71, 711-725.
Qian W, Choi S, Gibson GA, Watkins SC, Bakkenist CJ & Van Houten B (2012) Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci 125, 5745-5757.
Mitra K, Wunder C, Roysam B, Lin G & Lippincott-Schwartz J (2009) A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase. Proc Natl Acad Sci USA 106, 11960-11965.
Jourdain I, Gachet Y & Hyams JS (2009) The dynamin related protein Dnm1 fragments mitochondria in a microtubule-dependent manner during the fission yeast cell cycle. Cell Motil Cytoskeleton 66, 509-523.
Taguchi N, Ishihara N, Jofuku A, Oka T & Mihara K (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282, 11521-11529.
Tanaka K, Kanbe T & Kuroiwa T (1985) Three-dimensional behaviour of mitochondria during cell division and germ tube formation in the dimorphic yeast Candida albicans. J Cell Sci 73, 207-220.
Chen H, Chomyn A & Chan DC (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280, 26185-26192.