Knockout of Ca

Animals Calcium Channels, L-Type / deficiency Cyclic Nucleotide Phosphodiesterases, Type 6 / deficiency Disease Models, Animal Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Retinal Cone Photoreceptor Cells / metabolism Retinal Rod Photoreceptor Cells / metabolism Retinitis Pigmentosa / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
26 07 2021
Historique:
received: 06 05 2021
accepted: 09 07 2021
entrez: 27 7 2021
pubmed: 28 7 2021
medline: 4 11 2021
Statut: epublish

Résumé

Retinitis Pigmentosa is a genetically heterogeneous, degenerative retinal disorder characterized by gradual dysfunction and death of photoreceptors, first rods and later cones, and progressive blindness. Studies suggested that application of L-type calcium channel blockers rescues photoreceptors in paradigms related to Ca

Identifiants

DOI: 10.1038/s41598-021-94304-3 PMID: 34312410 PMC: PMC8313562
pubmed: 34312410
doi: 10.1038/s41598-021-94304-3
pii: 10.1038/s41598-021-94304-3
pmc: PMC8313562
doi:

Substances chimiques

Cacna1d protein, mouse 0
Calcium Channels, L-Type 0
Cyclic Nucleotide Phosphodiesterases, Type 6 EC 3.1.4.35
Pde6b protein, mouse EC 3.1.4.35

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15146

Informations de copyright

© 2021. The Author(s).

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Auteurs

Irem Kilicarslan (I)

Institute of Pharmacy, Pharmacology and Toxicology, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.

Lucia Zanetti (L)

Institute of Pharmacy, Pharmacology and Toxicology, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.

Elena Novelli (E)

CNR Neuroscience Institute, 56124, Pisa, Italy.

Christoph Schwarzer (C)

Department of Pharmacology, Medical University of Innsbruck, 6020, Innsbruck, Austria.

Enrica Strettoi (E)

CNR Neuroscience Institute, 56124, Pisa, Italy. enrica.strettoi@in.cnr.it.
Istituto Di Neuroscienze CNR, Area della Ricerca, Via Giuseppe Moruzzi 1, 56100, Pisa, Italy. enrica.strettoi@in.cnr.it.

Alexandra Koschak (A)

Institute of Pharmacy, Pharmacology and Toxicology, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria. alexandra.koschak@uibk.ac.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Knockout of Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type L › Knockout of Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › 3',5'-Cyclic-GMP Phosphodiesterases › Cyclic Nucleotide Phosphodiesterases, Type 6 › Knockout of Ca
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Knockout of Ca
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Knockout of Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Knockout of Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Knockout of Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Knockout of Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Knockout of Ca
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cellules photoréceptrices › Cellules photoréceptrices de vertébré › Cellules photoréceptrices en cône de la rétine › Knockout of Ca
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cellules photoréceptrices › Cellules photoréceptrices de vertébré › Cellules photoréceptrices en bâtonnet de la rétine › Knockout of Ca
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies héréditaires de l'oeil › Rétinite pigmentaire › Knockout of Ca