Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 07 2021
26 07 2021
Historique:
received:
28
04
2021
accepted:
07
07
2021
entrez:
27
7
2021
pubmed:
28
7
2021
medline:
4
11
2021
Statut:
epublish
Résumé
Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or hypoimmune states. Monocytes are central regulators of the inflammatory response, but our understanding of their role in the genesis and resolution of sepsis is still limited. Here, we report a comprehensive exploration of monocyte molecular responses in a cohort of patients with septic shock via proteomic profiling. The acute stage of septic shock was associated with an impaired inflammatory phenotype, indicated by the down-regulation of MHC class II molecules and proinflammatory cytokine pathways. Simultaneously, there was an up-regulation of glycolysis enzymes and a decrease in proteins related to the citric acid cycle and oxidative phosphorylation. On the other hand, the restoration of immunocompetence was the hallmark of recovering patients, in which an upregulation of interferon signaling pathways was a notable feature. Our results provide insights into the immunopathology of sepsis and propose that, pending future studies, immunometabolism pathway components could serve as therapeutic targets in septic patients.
Identifiants
pubmed: 34312428
doi: 10.1038/s41598-021-94474-0
pii: 10.1038/s41598-021-94474-0
pmc: PMC8313678
doi:
Substances chimiques
Cytokines
0
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15149Informations de copyright
© 2021. The Author(s).
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