Differentiation of exhausted CD8
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
18
05
2020
accepted:
22
06
2021
entrez:
27
7
2021
pubmed:
28
7
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8
Identifiants
pubmed: 34312544
doi: 10.1038/s41590-021-00982-6
pii: 10.1038/s41590-021-00982-6
pmc: PMC8323980
mid: NIHMS1717914
doi:
Substances chimiques
Antiviral Agents
0
Epitopes
0
Banques de données
ClinicalTrials.gov
['NCT02476617']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1030-1041Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA046277
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI131314
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI082630
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
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