NMR-based metabolomics associated with chronic kidney disease in humans and animals: a one health perspective.
Cat
Chronic kidney disease
Metabolite
Metabolomics
NMR
Journal
Molecular and cellular biochemistry
ISSN: 1573-4919
Titre abrégé: Mol Cell Biochem
Pays: Netherlands
ID NLM: 0364456
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
20
05
2021
accepted:
07
07
2021
pubmed:
28
7
2021
medline:
4
2
2022
entrez:
27
7
2021
Statut:
ppublish
Résumé
Chronic kidney disease (CKD) is a renal dysfunction that can lead to high rates of mortality and morbidity, particularly when coupled with late diagnosis. CKD has become a major health problem due to its challenging detection at early stages when clear symptoms are yet to be presented. Thus, CKD is likely to be identified when the substantive conditions of the disease are manifest. In order to address the development of the disease and provide necessary treatments at the initial stage, the investigation of new biomarkers and metabolites associated with early detection of CKD are needed. Identified metabolites could be used to confirm the presence of the disease, obtain information on its mechanism and facilitate the development of novel pharmaceutical treatments. Such metabolites may be detected from biofluids and tissues using a range of analytical techniques. There are a number of metabolites that have been identified by mass spectrometry at high sensitivities, whilst the detection of metabolites directly from biofluids using NMR could present a more rapid way to expand our understanding of this disease. This review is focused on NMR-based metabolomics associated with CKD in humans and animals.
Identifiants
pubmed: 34312783
doi: 10.1007/s11010-021-04222-1
pii: 10.1007/s11010-021-04222-1
pmc: PMC8473349
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4133-4137Informations de copyright
© 2021. The Author(s).
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