Determinism and variability of the morphogenesis pathways.
Cell potency
Embryo stem cells
Keywords: morphogenesis
Underdeveloped embryo
Journal
Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
11
12
2020
revised:
17
06
2021
accepted:
16
07
2021
pubmed:
28
7
2021
medline:
18
11
2021
entrez:
27
7
2021
Statut:
ppublish
Résumé
Along with a strict determinism of early embryogenesis in most living organisms, some of them exhibit variability of cell fates and developmental pathways. Here we discuss the phenomena of determinism and variability of developmental pathways, defining its dependence upon cell potency, cell sensitivity to the external signals and cell signaling. We propose a set of conjectures on the phenomenon of variability of developmental pathways, and denote a difference between a normal (local) variability, leading to an invariant final structure (e.g., embryo shape), and fundamental one, which is a switching between different developmental pathways, leading to different possible structures. For illustrating our conjectures, we analyzed early developmental stages of plant embryos with different levels of variability of morphogenesis pathways, and provide a set of computational experiments by Morphogenesis Software.
Identifiants
pubmed: 34314693
pii: S0012-1606(21)00172-X
doi: 10.1016/j.ydbio.2021.07.009
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.