The origins and potential future of SARS-CoV-2 variants of concern in the evolving COVID-19 pandemic.


Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
26 07 2021
Historique:
entrez: 27 7 2021
pubmed: 28 7 2021
medline: 12 8 2021
Statut: ppublish

Résumé

One year into the global COVID-19 pandemic, the focus of attention has shifted to the emergence and spread of SARS-CoV-2 variants of concern (VOCs). After nearly a year of the pandemic with little evolutionary change affecting human health, several variants have now been shown to have substantial detrimental effects on transmission and severity of the virus. Public health officials, medical practitioners, scientists, and the broader community have since been scrambling to understand what these variants mean for diagnosis, treatment, and the control of the pandemic through nonpharmaceutical interventions and vaccines. Here we explore the evolutionary processes that are involved in the emergence of new variants, what we can expect in terms of the future emergence of VOCs, and what we can do to minimise their impact.

Identifiants

pubmed: 34314723
pii: S0960-9822(21)00878-2
doi: 10.1016/j.cub.2021.06.049
pmc: PMC8220957
pii:
doi:

Substances chimiques

COVID-19 Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

R918-R929

Informations de copyright

Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Sarah P Otto (SP)

Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address: otto@zoology.ubc.ca.

Troy Day (T)

Department of Mathematics and Statistics, Department of Biology, Queen's University, Kingston, ON K7L 3N6, Canada.

Julien Arino (J)

Department of Mathematics and Data Science Nexus, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Caroline Colijn (C)

Department of Mathematics, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.

Jonathan Dushoff (J)

Department of Biology and M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.

Michael Li (M)

Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON N1G 3W4, Canada.

Samir Mechai (S)

Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, St. Hyacinthe, QC J2S 2M2, Canada.

Gary Van Domselaar (G)

National Microbiology Laboratory - Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Jianhong Wu (J)

Laboratory for Industrial and Applied Mathematics, York University, Toronto, ON M3J 1P3, Canada.

David J D Earn (DJD)

Department of Mathematics and Statistics and M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.

Nicholas H Ogden (NH)

Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, St. Hyacinthe, QC J2S 2M2, Canada.

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