Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
Journal
NAR cancer
ISSN: 2632-8674
Titre abrégé: NAR Cancer
Pays: England
ID NLM: 101769553
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
21
10
2020
revised:
27
01
2021
accepted:
28
02
2021
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Complex 1 (PRC1), which promotes the H2AK119ub catalytic activity of Ring1B, is upregulated in GBM and its tumorigenic role has been shown
Identifiants
pubmed: 34316702
doi: 10.1093/narcan/zcab009
pii: zcab009
pmc: PMC8210184
doi:
Types de publication
Journal Article
Langues
eng
Pagination
zcab009Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Cancer.
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