Vinothini Rajeeve

Affiliations

Integrative Cell Signalling & Proteomics, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Publications (27)

Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases.

Cell reports

Avec: David Bradley , Cristina Viéitez , Vinothini Rajeeve , Joel Selkrig , Pedro R Cutillas , Pedro Beltrao

Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.

NAR cancer

Avec: Verónica Freire-Benéitez , Nicola Pomella , Thomas O Millner , Anaëlle A Dumas , Maria Victoria Niklison-Chirou , Eleni Maniati , Jun Wang , Vinothini Rajeeve , Pedro Cutillas , Silvia Marino

Correction to 'Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma'.

NAR cancer

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion.

Cell reports

Avec: Elizabeth R Murray , Shinelle Menezes , Jack C Henry , Josie L Williams , Lorena Alba-Castellón , Priththivika Baskaran , Ivan Quétier , Ami Desai , Jacqueline J T Marshall , Ian Rosewell , Marianthi Tatari , Vinothini Rajeeve , Faraz Khan , Jun Wang , Panoraia Kotantaki , Eleanor J Tyler , Namrata Singh , Claire S Reader , Edward P Carter , Kairbaan Hodivala-Dilke , Richard P Grose , Hemant M Kocher , Nuria Gavara , Oliver Pearce , Pedro Cutillas , John F Marshall , Angus J M Cameron

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells.

FEBS open bio

Avec: Elliott M Thompson , Vruti Patel , Vinothini Rajeeve , Pedro R Cutillas , Andrew W Stoker

Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis.

Nature communications

Avec: E H Puttock , E J Tyler , M Manni , E Maniati , C Butterworth , M Burger Ramos , E Peerani , P Hirani , V Gauthier , Y Liu , G Maniscalco , V Rajeeve , P Cutillas , C Trevisan , M Pozzobon , M Lockley , J Rastrick , H Läubli , A White , O M T Pearce

FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.

EMBO molecular medicine

Avec: Sonia Zaghdoudi , Emilie Decaup , Ismahane Belhabib , Rémi Samain , Stéphanie Cassant-Sourdy , Julia Rochotte , Alexia Brunel , David Schlaepfer , Jérome Cros , Cindy Neuzillet , Manon Strehaiano , Amandine Alard , Richard Tomasini , Vinothini Rajeeve , Aurélie Perraud , Muriel Mathonnet , Oliver Mt Pearce , Yvan Martineau , Stéphane Pyronnet , Corinne Bousquet , Christine Jean

Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells.

Biomedicines

Avec: Nosheen Akhtar , Muhammad Waleed Baig , Ihsan-Ul Haq , Vinothini Rajeeve , Pedro Rodriguez Cutillas

TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer.

Cancer research

Avec: Laura S M Lecker , Chiara Berlato , Eleni Maniati , Robin Delaine-Smith , Oliver M T Pearce , Owen Heath , Samuel J Nichols , Caterina Trevisan , Marian Novak , Jacqueline McDermott , James D Brenton , Pedro R Cutillas , Vinothini Rajeeve , Ana Hennino , Ronny Drapkin , Daniela Loessner , Frances R Balkwill

Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth.

The Journal of pathology

Avec: Emma Newport , Ana Rita Pedrosa , Delphine Lees , Matthew Dukinfield , Edward Carter , Jesus Gomez-Escudero , Pedro Casado , Vinothini Rajeeve , Louise E Reynolds , Pedro R Cutillas , Stephen W Duffy , Beatriz De Luxán Delgado , Kairbaan Hodivala-Dilke

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes.

Signal transduction and targeted therapy

Avec: Pedro Casado , Ana Rio-Machin , Juho J Miettinen , Findlay Bewicke-Copley , Kevin Rouault-Pierre , Szilvia Krizsan , Alun Parsons , Vinothini Rajeeve , Farideh Miraki-Moud , David C Taussig , Csaba Bödör , John Gribben , Caroline Heckman , Jude Fitzgibbon , Pedro R Cutillas

Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor.

Blood

Avec: Sammy El-Mansi , Christopher L Robinson , Katja B Kostelnik , Jessica J McCormack , Tom P Mitchell , Damián Lobato-Márquez , Vinothini Rajeeve , Pedro Cutillas , Daniel F Cutler , Serge Mostowy , Thomas D Nightingale

Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer.

NPJ breast cancer

Avec: Emanuela Gadaleta , Pauline Fourgoux , Stefano Pirró , Graeme J Thorn , Rachel Nelan , Alastair Ironside , Vinothini Rajeeve , Pedro R Cutillas , Anna E Lobley , Jun Wang , Esteban Gea , Helen Ross-Adams , Conrad Bessant , Nicholas R Lemoine , Louise J Jones , Claude Chelala

Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs.

Nature communications

Avec: Henry Gerdes , Pedro Casado , Arran Dokal , Maruan Hijazi , Nosheen Akhtar , Ruth Osuntola , Vinothini Rajeeve , Jude Fitzgibbon , Jon Travers , David Britton , Shirin Khorsandi , Pedro R Cutillas

SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML.

Oncogene

Avec: Antonella Di Mambro , Yoana Arroyo-Berdugo , Tiziana Fioretti , Michael Randles , Luca Cozzuto , Vinothini Rajeeve , Armando Cevenini , Michael J Austin , Gabriella Esposito , Julia Ponomarenko , Claire M Lucas , Pedro Cutillas , John Gribben , Owen Williams , Yolanda Calle , Bela Patel , Maria Teresa Esposito

Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes.

Arthritis research & therapy

Avec: Cankut Çubuk , Rachel Lau , Pedro Cutillas , Vinothini Rajeeve , Christopher R John , Anna E A Surace , Rebecca Hands , Liliane Fossati-Jimack , Myles J Lewis , Costantino Pitzalis

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.

EMBO reports

Avec: Ruoyan Xu , William Jones , Ewa Wilcz-Villega , Ana Sh Costa , Vinothini Rajeeve , Robert B Bentham , Kevin Bryson , Ai Nagano , Busra Yaman , Sheila Olendo Barasa , Yewei Wang , Claude Chelala , Pedro Cutillas , Gyorgy Szabadkai , Christian Frezza , Katiuscia Bianchi

PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability.

The Biochemical journal

Avec: Sandra M Martín-Guerrero , Pedro Casado , Maruan Hijazi , Vinothini Rajeeve , Julio Plaza-Díaz , Francisco Abadía-Molina , Julio Navascués , Miguel A Cuadros , Pedro R Cutillas , David Martín-Oliva

Computational Analysis of Cholangiocarcinoma Phosphoproteomes Identifies Patient-Specific Drug Targets.

Cancer research

Avec: Shirin Elizabeth Khorsandi , Arran D Dokal , Vinothini Rajeeve , David J Britton , Megan S Illingworth , Nigel Heaton , Pedro R Cutillas

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis.

EBioMedicine

Avec: Kimberly Pistorius , Lucy Ly , Patricia R Souza , Esteban A Gomez , Duco S Koenis , Ana R Rodriguez , Julie Foster , Jane Sosabowski , Mark Hopkinson , Vinothini Rajeeve , Bernd W Spur , Andrew Pitsillides , Costantino Pitzalis , Jesmond Dalli

Versican associates with tumour immune phenotype and limits T cell trafficking via chondroitin sulfate.

Cancer research communications

Avec: Priyanka Hirani , Jacqueline McDermott , Vinothini Rajeeve , Pedro R Cutillas , J Louise Jones , Daniel J Pennington , Thomas N Wight , Salvatore Santamaria , Kimberly M Alonge , Oliver Matthew Thomas Pearce

Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of Glycolysis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Duco Steven Koenis , Roberta de Matteis , Vinothini Rajeeve , Pedro Cutillas , Jesmond Dalli

Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration.

PLoS biology

Avec: Katja B Kostelnik , Amy Barker , Christopher Schultz , Tom P Mitchell , Vinothini Rajeeve , Ian J White , Michel Aurrand-Lions , Sussan Nourshargh , Pedro Cutillas , Thomas D Nightingale

Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring.

Nature biotechnology

Avec: Maruan Hijazi , Ryan Smith , Vinothini Rajeeve , Conrad Bessant , Pedro R Cutillas

Cancer associated fibroblast FAK regulates malignant cell metabolism.

Nature communications

Avec: Fevzi Demircioglu , Jun Wang , Juliana Candido , Ana S H Costa , Pedro Casado , Beatriz de Luxan Delgado , Louise E Reynolds , Jesus Gomez-Escudero , Emma Newport , Vinothini Rajeeve , Ann-Marie Baker , Marina Roy-Luzarraga , Trevor A Graham , Julie Foster , Yu Wang , James J Campbell , Rajinder Singh , Penglie Zhang , Thomas J Schall , Frances R Balkwill , Jane Sosabowski , Pedro R Cutillas , Christian Frezza , Patricia Sancho , Kairbaan Hodivala-Dilke

Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment.

Cancer research

Avec: Marina Roy-Luzarraga , Louise E Reynolds , Beatriz de Luxán-Delgado , Oscar Maiques , Laura Wisniewski , Emma Newport , Vinothini Rajeeve , Rebecca J G Drake , Jesús Gómez-Escudero , Frances M Richards , Céline Weller , Christof Dormann , Ya-Ming Meng , Peter B Vermeulen , Dieter Saur , Victoria Sanz-Moreno , Ping-Pui Wong , Cyrill Géraud , Pedro R Cutillas , Kairbaan Hodivala-Dilke

eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors.

Molecular & cellular proteomics : MCP

Avec: Maruan Hijazi , Pedro Casado , Nosheen Akhtar , Saul Alvarez-Teijeiro , Vinothini Rajeeve , Pedro R Cutillas

Réseau de co-auteurs

Pedro R Cutillas 14 collaborations

Pedro Cutillas 9 collaborations

Pedro Casado 6 collaborations

Jun Wang 5 collaborations

Kairbaan Hodivala-Dilke 4 collaborations

Maruan Hijazi 4 collaborations

Eleni Maniati 3 collaborations

Nosheen Akhtar 3 collaborations

Emma Newport 3 collaborations

Louise E Reynolds 3 collaborations

Verónica Freire-Benéitez 2 collaborations

Nicola Pomella 2 collaborations

Thomas O Millner 2 collaborations

Anaëlle A Dumas 2 collaborations

Maria Victoria Niklison-Chirou 2 collaborations

Silvia Marino 2 collaborations

Jacqueline McDermott 2 collaborations

Frances R Balkwill 2 collaborations

Jesus Gomez-Escudero 2 collaborations

John Gribben 2 collaborations

Jude Fitzgibbon 2 collaborations

Katja B Kostelnik 2 collaborations

Tom P Mitchell 2 collaborations

Thomas D Nightingale 2 collaborations

Conrad Bessant 2 collaborations

Claude Chelala 2 collaborations

Costantino Pitzalis 2 collaborations

Christian Frezza 2 collaborations

Julie Foster 2 collaborations

Jane Sosabowski 2 collaborations

Jesmond Dalli 2 collaborations

Marina Roy-Luzarraga 2 collaborations

David Bradley 1 collaboration

Cristina Viéitez 1 collaboration

Joel Selkrig 1 collaboration

Pedro Beltrao 1 collaboration

Elizabeth R Murray 1 collaboration

Shinelle Menezes 1 collaboration

Jack C Henry 1 collaboration

Josie L Williams 1 collaboration

Lorena Alba-Castellón 1 collaboration

Priththivika Baskaran 1 collaboration

Ivan Quétier 1 collaboration

Ami Desai 1 collaboration

Jacqueline J T Marshall 1 collaboration

Ian Rosewell 1 collaboration

Marianthi Tatari 1 collaboration

Faraz Khan 1 collaboration

Panoraia Kotantaki 1 collaboration

Eleanor J Tyler 1 collaboration

Namrata Singh 1 collaboration

Claire S Reader 1 collaboration

Edward P Carter 1 collaboration

Richard P Grose 1 collaboration

Hemant M Kocher 1 collaboration

Nuria Gavara 1 collaboration

Oliver Pearce 1 collaboration

John F Marshall 1 collaboration

Angus J M Cameron 1 collaboration

Elliott M Thompson 1 collaboration

Vruti Patel 1 collaboration

Andrew W Stoker 1 collaboration

E H Puttock 1 collaboration

E J Tyler 1 collaboration

M Manni 1 collaboration

E Maniati 1 collaboration

C Butterworth 1 collaboration

M Burger Ramos 1 collaboration

E Peerani 1 collaboration

P Hirani 1 collaboration

V Gauthier 1 collaboration

Y Liu 1 collaboration

G Maniscalco 1 collaboration

V Rajeeve 1 collaboration

P Cutillas 1 collaboration

C Trevisan 1 collaboration

M Pozzobon 1 collaboration

M Lockley 1 collaboration

J Rastrick 1 collaboration

H Läubli 1 collaboration

A White 1 collaboration

O M T Pearce 1 collaboration

Sonia Zaghdoudi 1 collaboration

Emilie Decaup 1 collaboration

Ismahane Belhabib 1 collaboration

Rémi Samain 1 collaboration

Stéphanie Cassant-Sourdy 1 collaboration

Julia Rochotte 1 collaboration

Alexia Brunel 1 collaboration

David Schlaepfer 1 collaboration

Jérome Cros 1 collaboration

Cindy Neuzillet 1 collaboration

Manon Strehaiano 1 collaboration

Amandine Alard 1 collaboration

Richard Tomasini 1 collaboration

Aurélie Perraud 1 collaboration

Muriel Mathonnet 1 collaboration

Oliver Mt Pearce 1 collaboration

Yvan Martineau 1 collaboration

Stéphane Pyronnet 1 collaboration

Corinne Bousquet 1 collaboration

Christine Jean 1 collaboration

Muhammad Waleed Baig 1 collaboration

Ihsan-Ul Haq 1 collaboration

Pedro Rodriguez Cutillas 1 collaboration

Laura S M Lecker 1 collaboration

Chiara Berlato 1 collaboration

Robin Delaine-Smith 1 collaboration

Oliver M T Pearce 1 collaboration

Owen Heath 1 collaboration

Samuel J Nichols 1 collaboration

Caterina Trevisan 1 collaboration

Marian Novak 1 collaboration

James D Brenton 1 collaboration

Ana Hennino 1 collaboration

Ronny Drapkin 1 collaboration

Daniela Loessner 1 collaboration

Ana Rita Pedrosa 1 collaboration

Delphine Lees 1 collaboration

Matthew Dukinfield 1 collaboration

Edward Carter 1 collaboration

Stephen W Duffy 1 collaboration

Beatriz De Luxán Delgado 1 collaboration

Ana Rio-Machin 1 collaboration

Juho J Miettinen 1 collaboration

Findlay Bewicke-Copley 1 collaboration

Kevin Rouault-Pierre 1 collaboration

Szilvia Krizsan 1 collaboration

Alun Parsons 1 collaboration

Farideh Miraki-Moud 1 collaboration

David C Taussig 1 collaboration

Csaba Bödör 1 collaboration

Caroline Heckman 1 collaboration

Sammy El-Mansi 1 collaboration

Christopher L Robinson 1 collaboration

Jessica J McCormack 1 collaboration

Damián Lobato-Márquez 1 collaboration

Daniel F Cutler 1 collaboration

Serge Mostowy 1 collaboration

Emanuela Gadaleta 1 collaboration

Pauline Fourgoux 1 collaboration

Stefano Pirró 1 collaboration

Graeme J Thorn 1 collaboration

Rachel Nelan 1 collaboration

Alastair Ironside 1 collaboration

Anna E Lobley 1 collaboration

Esteban Gea 1 collaboration

Helen Ross-Adams 1 collaboration

Nicholas R Lemoine 1 collaboration

Louise J Jones 1 collaboration

Henry Gerdes 1 collaboration

Arran Dokal 1 collaboration

Ruth Osuntola 1 collaboration

Jon Travers 1 collaboration

David Britton 1 collaboration

Shirin Khorsandi 1 collaboration

Antonella Di Mambro 1 collaboration

Yoana Arroyo-Berdugo 1 collaboration

Tiziana Fioretti 1 collaboration

Michael Randles 1 collaboration

Luca Cozzuto 1 collaboration

Armando Cevenini 1 collaboration

Michael J Austin 1 collaboration

Gabriella Esposito 1 collaboration

Julia Ponomarenko 1 collaboration

Claire M Lucas 1 collaboration

Owen Williams 1 collaboration

Yolanda Calle 1 collaboration

Bela Patel 1 collaboration

Maria Teresa Esposito 1 collaboration

Cankut Çubuk 1 collaboration

Rachel Lau 1 collaboration

Christopher R John 1 collaboration

Anna E A Surace 1 collaboration

Rebecca Hands 1 collaboration

Liliane Fossati-Jimack 1 collaboration

Myles J Lewis 1 collaboration

Ruoyan Xu 1 collaboration

William Jones 1 collaboration

Ewa Wilcz-Villega 1 collaboration

Ana Sh Costa 1 collaboration

Robert B Bentham 1 collaboration

Kevin Bryson 1 collaboration

Ai Nagano 1 collaboration

Busra Yaman 1 collaboration

Sheila Olendo Barasa 1 collaboration

Yewei Wang 1 collaboration

Gyorgy Szabadkai 1 collaboration

Katiuscia Bianchi 1 collaboration

Sandra M Martín-Guerrero 1 collaboration

Julio Plaza-Díaz 1 collaboration

Francisco Abadía-Molina 1 collaboration

Julio Navascués 1 collaboration

Miguel A Cuadros 1 collaboration

David Martín-Oliva 1 collaboration

Shirin Elizabeth Khorsandi 1 collaboration

Arran D Dokal 1 collaboration

David J Britton 1 collaboration

Megan S Illingworth 1 collaboration

Nigel Heaton 1 collaboration

Kimberly Pistorius 1 collaboration

Lucy Ly 1 collaboration

Patricia R Souza 1 collaboration

Esteban A Gomez 1 collaboration

Duco S Koenis 1 collaboration

Ana R Rodriguez 1 collaboration

Mark Hopkinson 1 collaboration

Bernd W Spur 1 collaboration

Andrew Pitsillides 1 collaboration

Priyanka Hirani 1 collaboration

J Louise Jones 1 collaboration

Daniel J Pennington 1 collaboration

Thomas N Wight 1 collaboration

Salvatore Santamaria 1 collaboration

Kimberly M Alonge 1 collaboration

Oliver Matthew Thomas Pearce 1 collaboration

Duco Steven Koenis 1 collaboration

Roberta de Matteis 1 collaboration

Amy Barker 1 collaboration

Christopher Schultz 1 collaboration

Ian J White 1 collaboration

Michel Aurrand-Lions 1 collaboration

Sussan Nourshargh 1 collaboration

Ryan Smith 1 collaboration

Fevzi Demircioglu 1 collaboration

Juliana Candido 1 collaboration

Ana S H Costa 1 collaboration

Beatriz de Luxan Delgado 1 collaboration

Ann-Marie Baker 1 collaboration

Trevor A Graham 1 collaboration

Yu Wang 1 collaboration

James J Campbell 1 collaboration

Rajinder Singh 1 collaboration

Penglie Zhang 1 collaboration

Thomas J Schall 1 collaboration

Patricia Sancho 1 collaboration

Beatriz de Luxán-Delgado 1 collaboration

Oscar Maiques 1 collaboration

Laura Wisniewski 1 collaboration

Rebecca J G Drake 1 collaboration

Jesús Gómez-Escudero 1 collaboration

Frances M Richards 1 collaboration

Céline Weller 1 collaboration

Christof Dormann 1 collaboration

Ya-Ming Meng 1 collaboration

Peter B Vermeulen 1 collaboration

Dieter Saur 1 collaboration

Victoria Sanz-Moreno 1 collaboration

Ping-Pui Wong 1 collaboration

Cyrill Géraud 1 collaboration

Saul Alvarez-Teijeiro 1 collaboration