Trends and complications associated with acute new-onset heart failure: a National Readmissions Database-based cohort study.
Acute heart failure
Acute heart failure with preserved ejection fraction
Acute heart failure with reduced ejection fraction
HFpEF
HFrEF
Mortality trends
Journal
Heart failure reviews
ISSN: 1573-7322
Titre abrégé: Heart Fail Rev
Pays: United States
ID NLM: 9612481
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
accepted:
16
07
2021
pubmed:
29
7
2021
medline:
30
4
2022
entrez:
28
7
2021
Statut:
ppublish
Résumé
Literature regarding recent trends and outcomes of acute new-onset heart failure (AHF) with preserved ejection fraction (AHFpEF) and reduced ejection fraction (AHFrEF) is limited. The objective of this study is to study the outcomes of AHFpEF and AHFrEF in the USA. Data from the National Readmissions Database (NRD) sample that constitutes 49.1% of the stratified sample of all hospitals in the USA, representing more than 95% of the national population, were analyzed for hospitalization visits for acute heart failure. ICD-9 and ICD-10 codes were used to identify AHF. A total of 2,559,102 adult index AHF patients (mean age 70.79 ± 14.58 years, 49.4% females), 1,028,970 (40.2%) AHFpEF and 1,330,999 (52%) AHFrEF, were recorded in the National Readmissions Database for the years 2016-2018. A total of 152,465 (5.96%) acute heart failure, 47,271 (4.6%) AHFpEF and 91,973 (6.91%) AHFrEF, died during hospitalization, and 45,810 (1.9%) were readmitted in 30 days among alive discharges. Higher complication rates which included ventricular arrhythmias, acute coronary, and cerebrovascular events were observed among AHFrEF than AHFpEF. Higher proportion of patients with AHFrEF needed intensive care unit and ventilatory support during the hospitalization. The trend of incidence of AHFrEF, mortality among AHFrEF, and overall mortality worsened while AHFpEF improved over the study years 2012-2018 (p-trend < 0.05). Coronary procedures improved mortality rates among AHFpEF and AHFrEF. AHF is very common and is associated with significant mortality. The incidence of AHFrEF and mortality among AHFrEF had worsened, which calls for urgent intervention. Improved recognition of AHF is needed, and guideline-directed treatment of underlying risk factors including coronary artery disease can improve mortality. Graphic abstract of the analysis presented (created with BioRender.com).
Identifiants
pubmed: 34318388
doi: 10.1007/s10741-021-10152-3
pii: 10.1007/s10741-021-10152-3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
399-406Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Virani SS, Alonso A, Aparicio HJ et al (2021) Heart disease and stroke statistics—2021 update. Circulation 143(8):e254–e743
doi: 10.1161/CIR.0000000000000950
Benjamin EJ, Muntner P, Alonso A et al (2019) Heart disease and stroke statistics—2019 update: a report from the American Heart Association. Circulation 139(10):e56–e528
doi: 10.1161/CIR.0000000000000659
Members WG, Lloyd-Jones D, Adams RJ et al (2010) Executive summary: heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation 121(7):948–954
doi: 10.1161/CIRCULATIONAHA.109.192666
Benjamin EJ, Virani SS, Callaway CW et al (2018) Heart disease and stroke statistics—2018 update: a report from the American Heart Association. Circulation 137(12):e67–e492
doi: 10.1161/CIR.0000000000000558
Kannel WB, Hjortland M, Castelli WP (1974) Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 34(1):29–34
doi: 10.1016/0002-9149(74)90089-7
Spinar J, Parenica J, Vitovec J et al (2011) Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) main registry. Crit Care 15(6):R291
doi: 10.1186/cc10584
Greenberg BH, Abraham WT, Albert NM et al (2007) Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: a report from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). Am Heart J 154(2):277.e271-277.e278
doi: 10.1016/j.ahj.2007.05.001
NRD Database Documentation (2017) Rockville, MD Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project (HCUP). http://www.hcup-usahrqgov/db/nation/nrd/nrddbdocumentationjsp . Accessed 27 Dec 2017
Agency for Healthcare Research and Quality, Rockville, MD (2014) introduction to the NEDS. Healthcare Cost and Utilization Project (HCUP). https://hcup-us-ahrq-gov.proxy.lib.wayne.edu/db/nation/neds/NEDS_Introduction_2014.jsp . Updated 2018. [Accessed 18 Dec 2019]
StataCorp (2019) Stata statistical software: release 16. StataCorp LLC, College Station, TX
Gomez-Soto FM, Andrey JL, Garcia-Egido AA et al (2011) Incidence and mortality of heart failure: a community-based study. Int J Cardiol 151(1):40–45
doi: 10.1016/j.ijcard.2010.04.055
Kelly DJ, Gershlick T, Witzenbichler B et al (2011) Incidence and predictors of heart failure following percutaneous coronary intervention in ST-segment elevation myocardial infarction: the HORIZONS-AMI trial. Am Heart J 162(4):663–670
doi: 10.1016/j.ahj.2011.08.002
van der Vleuten PA, Rasoul S, Huurnink W et al (2008) The importance of left ventricular function for long-term outcome after primary percutaneous coronary intervention. BMC Cardiovasc Disord 8(1):1–7
doi: 10.1186/1471-2261-8-1
Hashmi KA, Abbas K, Hashmi AA et al (2018) In-hospital mortality of patients with cardiogenic shock after acute myocardial infarction; impact of early revascularization. BMC Res Notes 11(1):721
doi: 10.1186/s13104-018-3830-7
Kalogirou F, Forsyth F, Kyriakou M, Mantle R, Deaton C (2020) Heart failure disease management: a systematic review of effectiveness in heart failure with preserved ejection fraction. ESC Heart Fail 7(1):194–212
pubmed: 31978280
pmcid: 7083420
Khan MS, Sreenivasan J, Lateef N et al (2021) Trends in 30-and 90-day readmission rates for heart failure. Circ Heart Fail 14(4):e008335
Allen LA, Hernandez AF, Peterson ED et al (2011) Discharge to a skilled nursing facility and subsequent clinical outcomes among older patients hospitalized for heart failure. Circ Heart Fail 4(3):293–300