Efficacy of a strategy-based intervention on text-level reading comprehension in persons with aphasia: a study protocol for a repeated measures study.
adult neurology
clinical trials
rehabilitation medicine
stroke
therapeutics
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
28 07 2021
28 07 2021
Historique:
entrez:
29
7
2021
pubmed:
30
7
2021
medline:
5
8
2021
Statut:
epublish
Résumé
At least 68% of persons with aphasia (PWA) experience reading difficulties. Even though strategy-based interventions are a promising treatment approach for text level reading comprehension deficits in PWA, empirical evidence for their efficacy remains rare. The primary objective of this study is the analysis of the efficacy of a strategy-based intervention on text-level reading comprehension and on reading activities in PWA. In a repeated measures trial, 24 PWA will first participate in a waiting period and then in a strategy-based intervention (14 face-to-face-sessions, 60 min each). We will apply two combinations of strategies to treat either the microstructure or the macrostructure, respectively. Participants will be randomly allocated to two parallel groups that will receive these combinations in interchanged sequences. Assessments will be implemented before and after each period as well as 3 and 6 months after the intervention. The primary outcome measure is text-level reading comprehension measured with a German version of the Test de Compréhension de Textes (TCT-D) and represented by the score TCT-D Total . A non-blinded and a blinded rater will evaluate the primary outcome measure. Secondary outcome measures will address specific reading functions, reading activities and cognitive functions. The sample size was determined with an a priori power analysis. For statistical analysis, we will use contrast analyses within repeated measures analysis of variance models. We expect significant improvements in primary and secondary outcome measures during the intervention as compared with changes during the waiting period. This study was approved by the ethics committee of Deutscher Bundesverband für akademische Sprachtherapie und Logopädie (20-10074-KA-MunmErw+Ko). Results and relevant data will be disseminated in peer-reviewed journals, at conferences and on the Open Science Framework. DRKS00021411 (see Supplementary Table 1).
Identifiants
pubmed: 34321303
pii: bmjopen-2020-048126
doi: 10.1136/bmjopen-2020-048126
pmc: PMC8319981
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e048126Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Stroke. 2011 May;42(5):1398-403
pubmed: 21441153
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2557-2560
pubmed: 29487213
Brain Lang. 2001 Aug;78(2):254-7
pubmed: 11500074
Am J Speech Lang Pathol. 2013 May;22(2):S318-33
pubmed: 23695908
PLoS Med. 2007 Feb;4(2):e61
pubmed: 17311468
Am J Speech Lang Pathol. 2014 May;23(2):160-75
pubmed: 24687229
Can J Surg. 2010 Oct;53(5):345-8
pubmed: 20858381
J Speech Lang Hear Res. 1997 Jun;40(3):493-507
pubmed: 9210109
Neurol Sci. 2019 Oct;40(10):2141-2146
pubmed: 31183673
Disabil Rehabil. 2017 Feb;39(4):315-337
pubmed: 26887257
NeuroRehabilitation. 2007;22(4):303-10
pubmed: 17971621
Lancet. 2017 Apr 15;389(10078):1528-1538
pubmed: 28256356
Semin Speech Lang. 2010 Feb;31(1):42-51
pubmed: 20379961
Semin Speech Lang. 2007 Nov;28(4):244-53
pubmed: 17935009
Ann Intern Med. 2013 Feb 5;158(3):200-7
pubmed: 23295957