Region-specific elevations of glutamate + glutamine correlate with the sensory symptoms of autism spectrum disorders.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
received:
08
03
2021
accepted:
10
06
2021
revised:
04
06
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Individuals on the autism spectrum are often reported as being hyper- and/or hyporeactive to sensory input. These sensory symptoms were one of the key observations that led to the development of the altered excitation-inhibition (E-I) model of autism, which posits that an increase ratio of excitatory to inhibitory signaling may explain certain phenotypical expressions of autism spectrum disorders (ASD). While there has been strong support for the altered E-I model of autism, much of the evidence has come from animal models. With regard to in-vivo human studies, evidence for altered E-I balance in ASD come from studies adopting magnetic resonance spectroscopy (MRS). Spectral-edited MRS can be used to provide measures of the levels of GABA + (GABA + macromolecules) and Glx (glutamate + glutamine) in specific brain regions as proxy markers of inhibition and excitation respectively. In the current study, we found region-specific elevations of Glx in the primary sensorimotor cortex (SM1) in ASD. There were no group differences of GABA+ in either the SM1 or thalamus. Higher levels of Glx were associated with more parent reported difficulties of sensory hyper- and hyporeactivity, as well as reduced feed-forward inhibition during tactile perception in children with ASD. Critically, the finding of elevated Glx provides strong empirical support for increased excitation in ASD. Our results also provide a clear link between Glx and the sensory symptoms of ASD at both behavioral and perceptual levels.
Identifiants
pubmed: 34326312
doi: 10.1038/s41398-021-01525-1
pii: 10.1038/s41398-021-01525-1
pmc: PMC8322079
doi:
Substances chimiques
Glutamine
0RH81L854J
Glutamic Acid
3KX376GY7L
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
411Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB031771
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG062230
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD100869
Pays : United States
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R00 MH107719
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015909
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH098228
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH078160
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106564
Pays : United States
Informations de copyright
© 2021. The Author(s).
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