The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development.
DNA demethylation
epigenetic
evolution
long non-coding RNA
mammal
promoter
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
27 10 2021
27 10 2021
Historique:
received:
04
02
2021
revised:
13
05
2021
accepted:
16
07
2021
pubmed:
31
7
2021
medline:
7
4
2022
entrez:
30
7
2021
Statut:
ppublish
Résumé
Increasing evidence has shown that many long non-coding RNAs (lncRNAs) are involved in gene regulation in a variety of ways such as transcriptional, post-transcriptional and epigenetic regulation. Promoter-associated non-coding RNAs (pancRNAs), which are categorized into the most abundant single-copy lncRNA biotype, play vital regulatory roles in finely tuning cellular specification at the epigenomic level. In short, pancRNAs can directly or indirectly regulate downstream genes to participate in the development of organisms in a cell-specific manner. In this review, we will introduce the evolutionarily acquired characteristics of pancRNAs as determined by comparative epigenomics and elaborate on the research progress on pancRNA-involving processes in mammalian embryonic development, including neural differentiation.
Identifiants
pubmed: 34328174
pii: 229419
doi: 10.1042/EBC20200143
doi:
Substances chimiques
RNA, Long Noncoding
0
RNA, Untranslated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
697-708Informations de copyright
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.