Patients' perspectives on the derivation and use of organoids.
ethics
organoids
patient perspectives
qualitative research
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
12
05
2021
revised:
29
06
2021
accepted:
02
07
2021
pubmed:
31
7
2021
medline:
15
3
2022
entrez:
30
7
2021
Statut:
ppublish
Résumé
Organoid research is enhancing understanding of human development and diseases as well as aiding in medication development and selection, raising hopes for even more future therapeutic options. Nevertheless, this work raises important ethical issues and there is a paucity of data regarding patients' perspectives on them. We report on 60 interviews with adult patients or parents of pediatric patients from diverse disease populations who receive medical care at a major academic research institution in the United States. Interviewees expressed broad support for organoid development and use. However, patients viewed brain organoids, and sometimes gonadal organoids, as morally distinct; and some organoid research poses moral concerns. Nonetheless, patients generally understood the potential value of such research and approved of it, provided it was aimed at good intent and conducted with ethical oversight and a robust consent process. These data should help inform conceptual and policy deliberations about appropriate organoid use.
Identifiants
pubmed: 34329595
pii: S2213-6711(21)00329-5
doi: 10.1016/j.stemcr.2021.07.004
pmc: PMC8365094
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1874-1883Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK103168
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK085532
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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