Mark Donowitz

Affiliations

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publications (36)

Challenges in IBD Research: Preclinical Human IBD Mechanisms.

Inflammatory bowel diseases

Avec: Theresa T Pizarro , Thaddeus S Stappenbeck , Florian Rieder , Michael J Rosen , Jean-Frédéric Colombel , Mark Donowitz , Jennifer Towne , Sarkis K Mazmanian , Jeremiah J Faith , Richard A Hodin , Wendy S Garrett , Alessandro Fichera , Lisa S Poritz , Constanza J Cortes , Nataly Shtraizent , Gerard Honig , Scott B Snapper , Andrés Hurtado-Lorenzo , Nita H Salzman , Eugene B Chang

Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.

eLife

Avec: Magdalena Kasendra , Raymond Luc , Jianyi Yin , Dimitris V Manatakis , Gauri Kulkarni , Carolina Lucchesi , Josiah Sliz , Athanasia Apostolou , Laxmi Sunuwar , Jenifer Obrigewitch , Kyung-Jin Jang , Geraldine A Hamilton , Mark Donowitz , Katia Karalis

Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways.

American journal of physiology. Cell physiology

Avec: Kelli Johnson , Jianyi Yin , Julie G In , Subhash Kulkarni , Pankaj Pasricha , Chung Ming Tse , Mark Donowitz

Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Sarah E Blutt , Sue E Crawford , Carolyn Bomidi , Xi-Lei Zeng , James R Broughman , Matthew Robertson , Cristian Coarfa , Mary Elizabeth M Tessier , Tor Savidge , F Blaine Hollinger , Steven A Curley , Mark Donowitz , Mary K Estes

cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity.

Cellular and molecular gastroenterology and hepatology

Avec: Chung-Ming Tse , Jianyi Yin , Varsha Singh , Rafiquel Sarker , Ruxian Lin , Alan S Verkman , Jerrold R Turner , Mark Donowitz

Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model.

Infection and immunity

Avec: Laxmi Sunuwar , Jianyi Yin , Magdalena Kasendra , Katia Karalis , James Kaper , James Fleckenstein , Mark Donowitz

Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function.

Cellular and molecular gastroenterology and hepatology

Avec: Varsha Singh , Kelli Johnson , Jianyi Yin , Sun Lee , Ruxian Lin , Huimin Yu , Julie In , Jennifer Foulke-Abel , Nicholas C Zachos , Mark Donowitz , Yan Rong

Identification of Intestinal NaCl Absorptive-Anion Secretory Cells: Potential Functional Significance.

Frontiers in physiology

Avec: Mark Donowitz , Rafiquel Sarker , Ruxian Lin , George McNamara , Chung Ming Tse , Varsha Singh

A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity.

Gastroenterology

Avec: Nicholas C Zachos , Hannah Vaughan , Rafiquel Sarker , Savannah Est-Witte , Molee Chakraborty , Nicholas W Baetz , Hongzhe Yu , Vladimir Yarov-Yarovoy , George McNamara , Jordan J Green , Chung-Ming Tse , Mark Donowitz

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic

Gut microbes

Avec: Jennifer Foulke-Abel , Huimin Yu , Laxmi Sunuwar , Ruxian Lin , James M Fleckenstein , James B Kaper , Mark Donowitz

Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease.

JCI insight

Avec: Laxmi Sunuwar , Azra Frkatović , Sodbo Sharapov , Qinchuan Wang , Heather M Neu , Xinqun Wu , Talin Haritunians , Fengyi Wan , Sarah Michel , Shaoguang Wu , Mark Donowitz , Dermot McGovern , Gordan Lauc , Cynthia Sears , Joanna Melia

Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases.

World journal of gastroenterology

Avec: Jun-Hwan Yoo , Mark Donowitz

Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling.

Cellular and molecular gastroenterology and hepatology

Avec: Huimin Yu , Zixin Zhang , Gangping Li , Yan Feng , Lingling Xian , Fatemeh Bakhsh , Dongqing Xu , Cheng Xu , Tyrus Vong , Bin Wu , Florin M Selaru , Fengyi Wan , Mark Donowitz , G William Wong

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.

iScience

Avec: Luke Reilly , Evan R Semenza , George Koshkaryan , Subrata Mishra , Sujan Chatterjee , Efrat Abramson , Pamela Mishra , Yoshitasu Sei , Stephen A Wank , Mark Donowitz , Solomon H Snyder , Prasun Guha

The Air-Liquid Interface Reorganizes Membrane Lipids and Enhances the Recruitment of Slc26a3 to Lipid-Rich Domains in Human Colonoid Monolayers.

International journal of molecular sciences

Avec: C Ming Tse , Zixin Zhang , Ruxian Lin , Rafiquel Sarker , Mark Donowitz , Varsha Singh

Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment.

Scientific reports

Avec: Vishwesh Bharadiya , Yan Rong , Zixin Zhang , Ruxian Lin , Anthony Lawrence Guerrerio , C Ming Tse , Mark Donowitz , Varsha Singh

Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli.

Scientific reports

Avec: Lixia Liu , Waleska Saitz-Rojas , Rachel Smith , Laura Gonyar , Julie G In , Olga Kovbasnjuk , Nicholas C Zachos , Mark Donowitz , James P Nataro , Fernando Ruiz-Perez

Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease.

Biochemical and biophysical research communications

Avec: Joanna M P Melia , Ruxian Lin , Ramnik J Xavier , Richard B Thompson , Dax Fu , Fengyi Wan , Cynthia L Sears , Mark Donowitz

Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Jianyi Yin , Laxmi Sunuwar , Magdalena Kasendra , Huimin Yu , Chung-Ming Tse , C Conover Talbot , Tatiana Boronina , Robert Cole , Katia Karalis , Mark Donowitz

Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury.

iScience

Avec: Julie G In , Jianyi Yin , Roger Atanga , Michele Doucet , Robert N Cole , Lauren DeVine , Mark Donowitz , Nicholas C Zachos , Sarah E Blutt , Mary K Estes , Olga Kovbasnjuk

Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Jessica S Smyth , Jennifer K Truong , Anuradha Rao , Ruxian Lin , Jennifer Foulke-Abel , Luciano Adorini , Mark Donowitz , Paul A Dawson , Stephen J Keely

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling: IAFs disrupt colon epithelium via PGE2-EP4.

bioRxiv : the preprint server for biology

Avec: Yi Dong , Blake A Johnson , Linhao Ruan , Maged Zeineldin , Albert Z Liu , Sumana Raychaudhuri , Ian Chiu , Jin Zhu , Barbara Smith , Nan Zhao , Peter Searson , Shigeki Watanabe , Mark Donowitz , Tatianna C Larman , Rong Li

Human Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Christopher Arian , Eimear O Mahony , James W MacDonald , Theo K Bammler , Mark Donowitz , Edward J Kelly , Kenneth E Thummel

Host-derived CEACAM-laden vesicles engage enterotoxigenic

bioRxiv : the preprint server for biology

Avec: Alaullah Sheikh , Debayan Ganguli , Tim J Vickers , Bernhard Singer , Jennifer Foulke-Abel , Marjahan Akhtar , Nazia Khatoon , Bipul Setu , Supratim Basu , Clayton Harro , Nicole Maier , Wandy L Beatty , Subhra Chakraborty , Tafiqur R Bhuiyan , Firdausi Qadri , Mark Donowitz , James M Fleckenstein

Host-derived CEACAM-laden vesicles engage enterotoxigenic

Proceedings of the National Academy of Sciences of the United States of America

Avec: Alaullah Sheikh , Debayan Ganguli , Tim J Vickers , Bernhard B Singer , Jennifer Foulke-Abel , Marjahan Akhtar , Nazia Khatoon , Bipul Setu , Supratim Basu , Clayton Harro , Nicole Maier , Wandy L Beatty , Subhra Chakraborty , Taufiqur R Bhuiyan , Firdausi Qadri , Mark Donowitz , James M Fleckenstein

SARS-COV-2 induced Diarrhea is inflammatory, Ca

bioRxiv : the preprint server for biology

Avec: Mark Donowitz , Chung-Ming Tse , Karol Dokladny , Manmeet Rawat , Ivy Horwitz , Chunyan Ye , Alison Kell , Ruxian Lin , Sun Lee , Chenxu Guo , Shang Jui Tsai , Andrea Cox , Stephen Gould , Julie In , Steven Bradfute , Nicholas C Zachos , Olga Kovbasnjuk

Use of organoids to study regenerative responses to intestinal damage.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Sarah E Blutt , Ophir D Klein , Mark Donowitz , Noah Shroyer , Chandan Guha , Mary K Estes

NHERF3 is necessary for

American journal of physiology. Cell physiology

Avec: Tiane Chen , Ruxian Lin , Leela Avula , Rafiquel Sarker , Jianbo Yang , Boyoung Cha , Chung Ming Tse , George McNamara , Ursula Seidler , Scott Waldman , Adam Snook , Marcel J C Bijvelds , Hugo R de Jonge , Xuhang Li , Mark Donowitz

Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Tianying Duan , Onur Cil , C Ming Tse , Rafiquel Sarker , Ruxian Lin , Mark Donowitz , Alan S Verkman

Challenges in IBD Research: Novel Technologies.

Inflammatory bowel diseases

Avec: Manish Dhyani , Nitin Joshi , Willem A Bemelman , Michael S Gee , Vijay Yajnik , André D'Hoore , Giovanni Traverso , Mark Donowitz , Gustavo Mostoslavsky , Timothy K Lu , Neil Lineberry , Heiko G Niessen , Dan Peer , Jonathan Braun , Conor P Delaney , Marla C Dubinsky , Ashley N Guillory , Maria Pereira , Nataly Shtraizent , Gerard Honig , David Brent Polk , Andrés Hurtado-Lorenzo , Jeffrey M Karp , Fabrizio Michelassi

Patients' perspectives on the derivation and use of organoids.

Stem cell reports

Avec: Juli Bollinger , Elizabeth May , Debra Mathews , Mark Donowitz , Jeremy Sugarman

mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Avec: Rafiquel Sarker , Chung Ming Tse , Ruxian Lin , George McNamara , Varsha Singh , Mark Donowitz

COVID-19 diarrhea is inflammatory, caused by direct viral effects plus major role of virus-induced cytokines.

Cellular and molecular gastroenterology and hepatology

Avec: Mark Donowitz , Chung-Ming Tse , Rafiq Sarker , Ruxian Lin , Karol Dokladny , Manmeet Rawat , Ivy Horwitz , ChunYan Ye , G McNamara , Julie In , Alison Kell , Chenxu Guo , Shang JuiTsai , Tyrus Vong , Andrew Karaba , Varsha Singh , Jaiprasath Sachithanandhan , Andy Pekosz , Andrea Cox , Steven Bradfute , Nicholas C Zachos , Steven Gould , Olga Kovbasnjuk

SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca

American journal of physiology. Cell physiology

Avec: Rafiquel Sarker , Ruxian Lin , Varsha Singh , Mark Donowitz , Chung-Ming Tse

Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.

Translational research : the journal of laboratory and clinical medicine

Avec: Tifany Chu , Pattareeya Yottasan , Livia de Souza Goncalves , Apurva A Oak , Ruxian Lin , Ming Tse , Mark Donowitz , Onur Cil

Disruption of epithelium integrity by inflammation-associated fibroblasts through prostaglandin signaling.

Science advances

Avec: Yi Dong , Blake A Johnson , Linhao Ruan , Maged Zeineldin , Tianhao Bi , Albert Z Liu , Sumana Raychaudhuri , Ian Chiu , Jin Zhu , Barbara Smith , Nan Zhao , Peter Searson , Shigeki Watanabe , Mark Donowitz , Tatianna C Larman , Rong Li

Réseau de co-auteurs

Ruxian Lin 15 collaborations

Varsha Singh 8 collaborations

Rafiquel Sarker 8 collaborations

Jianyi Yin 7 collaborations

Chung-Ming Tse 6 collaborations

Nicholas C Zachos 6 collaborations

Laxmi Sunuwar 5 collaborations

Jennifer Foulke-Abel 5 collaborations

Chung Ming Tse 4 collaborations

Huimin Yu 4 collaborations

George McNamara 4 collaborations

Olga Kovbasnjuk 4 collaborations

Magdalena Kasendra 3 collaborations

Katia Karalis 3 collaborations

Julie G In 3 collaborations

Sarah E Blutt 3 collaborations

Mary K Estes 3 collaborations

Julie In 3 collaborations

James M Fleckenstein 3 collaborations

Fengyi Wan 3 collaborations

Zixin Zhang 3 collaborations

C Ming Tse 3 collaborations

Nataly Shtraizent 2 collaborations

Gerard Honig 2 collaborations

Andrés Hurtado-Lorenzo 2 collaborations

Kelli Johnson 2 collaborations

Alan S Verkman 2 collaborations

Sun Lee 2 collaborations

Yan Rong 2 collaborations

Tyrus Vong 2 collaborations

Yi Dong 2 collaborations

Blake A Johnson 2 collaborations

Linhao Ruan 2 collaborations

Maged Zeineldin 2 collaborations

Albert Z Liu 2 collaborations

Sumana Raychaudhuri 2 collaborations

Ian Chiu 2 collaborations

Jin Zhu 2 collaborations

Barbara Smith 2 collaborations

Nan Zhao 2 collaborations

Peter Searson 2 collaborations

Shigeki Watanabe 2 collaborations

Tatianna C Larman 2 collaborations

Rong Li 2 collaborations

Alaullah Sheikh 2 collaborations

Debayan Ganguli 2 collaborations

Tim J Vickers 2 collaborations

Marjahan Akhtar 2 collaborations

Nazia Khatoon 2 collaborations

Bipul Setu 2 collaborations

Supratim Basu 2 collaborations

Clayton Harro 2 collaborations

Nicole Maier 2 collaborations

Wandy L Beatty 2 collaborations

Subhra Chakraborty 2 collaborations

Firdausi Qadri 2 collaborations

Karol Dokladny 2 collaborations

Manmeet Rawat 2 collaborations

Ivy Horwitz 2 collaborations

Alison Kell 2 collaborations

Chenxu Guo 2 collaborations

Andrea Cox 2 collaborations

Steven Bradfute 2 collaborations

Onur Cil 2 collaborations

Theresa T Pizarro 1 collaboration

Thaddeus S Stappenbeck 1 collaboration

Florian Rieder 1 collaboration

Michael J Rosen 1 collaboration

Jean-Frédéric Colombel 1 collaboration

Jennifer Towne 1 collaboration

Sarkis K Mazmanian 1 collaboration

Jeremiah J Faith 1 collaboration

Richard A Hodin 1 collaboration

Wendy S Garrett 1 collaboration

Alessandro Fichera 1 collaboration

Lisa S Poritz 1 collaboration

Constanza J Cortes 1 collaboration

Scott B Snapper 1 collaboration

Nita H Salzman 1 collaboration

Eugene B Chang 1 collaboration

Raymond Luc 1 collaboration

Dimitris V Manatakis 1 collaboration

Gauri Kulkarni 1 collaboration

Carolina Lucchesi 1 collaboration

Josiah Sliz 1 collaboration

Athanasia Apostolou 1 collaboration

Jenifer Obrigewitch 1 collaboration

Kyung-Jin Jang 1 collaboration

Geraldine A Hamilton 1 collaboration

Subhash Kulkarni 1 collaboration

Pankaj Pasricha 1 collaboration

Sue E Crawford 1 collaboration

Carolyn Bomidi 1 collaboration

Xi-Lei Zeng 1 collaboration

James R Broughman 1 collaboration

Matthew Robertson 1 collaboration

Cristian Coarfa 1 collaboration

Mary Elizabeth M Tessier 1 collaboration

Tor Savidge 1 collaboration

F Blaine Hollinger 1 collaboration

Steven A Curley 1 collaboration

Jerrold R Turner 1 collaboration

James Kaper 1 collaboration

James Fleckenstein 1 collaboration

Hannah Vaughan 1 collaboration

Savannah Est-Witte 1 collaboration

Molee Chakraborty 1 collaboration

Nicholas W Baetz 1 collaboration

Hongzhe Yu 1 collaboration

Vladimir Yarov-Yarovoy 1 collaboration

Jordan J Green 1 collaboration

James B Kaper 1 collaboration

Azra Frkatović 1 collaboration

Sodbo Sharapov 1 collaboration

Qinchuan Wang 1 collaboration

Heather M Neu 1 collaboration

Xinqun Wu 1 collaboration

Talin Haritunians 1 collaboration

Sarah Michel 1 collaboration

Shaoguang Wu 1 collaboration

Dermot McGovern 1 collaboration

Gordan Lauc 1 collaboration

Cynthia Sears 1 collaboration

Joanna Melia 1 collaboration

Jun-Hwan Yoo 1 collaboration

Gangping Li 1 collaboration

Yan Feng 1 collaboration

Lingling Xian 1 collaboration

Fatemeh Bakhsh 1 collaboration

Dongqing Xu 1 collaboration

Cheng Xu 1 collaboration

Bin Wu 1 collaboration

Florin M Selaru 1 collaboration

G William Wong 1 collaboration

Luke Reilly 1 collaboration

Evan R Semenza 1 collaboration

George Koshkaryan 1 collaboration

Subrata Mishra 1 collaboration

Sujan Chatterjee 1 collaboration

Efrat Abramson 1 collaboration

Pamela Mishra 1 collaboration

Yoshitasu Sei 1 collaboration

Stephen A Wank 1 collaboration

Solomon H Snyder 1 collaboration

Prasun Guha 1 collaboration

Vishwesh Bharadiya 1 collaboration

Anthony Lawrence Guerrerio 1 collaboration

Lixia Liu 1 collaboration

Waleska Saitz-Rojas 1 collaboration

Rachel Smith 1 collaboration

Laura Gonyar 1 collaboration

James P Nataro 1 collaboration

Fernando Ruiz-Perez 1 collaboration

Joanna M P Melia 1 collaboration

Ramnik J Xavier 1 collaboration

Richard B Thompson 1 collaboration

Dax Fu 1 collaboration

Cynthia L Sears 1 collaboration

C Conover Talbot 1 collaboration

Tatiana Boronina 1 collaboration

Robert Cole 1 collaboration

Roger Atanga 1 collaboration

Michele Doucet 1 collaboration

Robert N Cole 1 collaboration

Lauren DeVine 1 collaboration

Jessica S Smyth 1 collaboration

Jennifer K Truong 1 collaboration

Anuradha Rao 1 collaboration

Luciano Adorini 1 collaboration

Paul A Dawson 1 collaboration

Stephen J Keely 1 collaboration

Christopher Arian 1 collaboration

Eimear O Mahony 1 collaboration

James W MacDonald 1 collaboration

Theo K Bammler 1 collaboration

Edward J Kelly 1 collaboration

Kenneth E Thummel 1 collaboration

Bernhard Singer 1 collaboration

Tafiqur R Bhuiyan 1 collaboration

Bernhard B Singer 1 collaboration

Taufiqur R Bhuiyan 1 collaboration

Chunyan Ye 1 collaboration

Shang Jui Tsai 1 collaboration

Stephen Gould 1 collaboration

Ophir D Klein 1 collaboration

Noah Shroyer 1 collaboration

Chandan Guha 1 collaboration

Tiane Chen 1 collaboration

Leela Avula 1 collaboration

Jianbo Yang 1 collaboration

Boyoung Cha 1 collaboration

Ursula Seidler 1 collaboration

Scott Waldman 1 collaboration

Adam Snook 1 collaboration

Marcel J C Bijvelds 1 collaboration

Hugo R de Jonge 1 collaboration

Xuhang Li 1 collaboration

Tianying Duan 1 collaboration

Manish Dhyani 1 collaboration

Nitin Joshi 1 collaboration

Willem A Bemelman 1 collaboration

Michael S Gee 1 collaboration

Vijay Yajnik 1 collaboration

André D'Hoore 1 collaboration

Giovanni Traverso 1 collaboration

Gustavo Mostoslavsky 1 collaboration

Timothy K Lu 1 collaboration

Neil Lineberry 1 collaboration

Heiko G Niessen 1 collaboration

Dan Peer 1 collaboration

Jonathan Braun 1 collaboration

Conor P Delaney 1 collaboration

Marla C Dubinsky 1 collaboration

Ashley N Guillory 1 collaboration

Maria Pereira 1 collaboration

David Brent Polk 1 collaboration

Jeffrey M Karp 1 collaboration

Fabrizio Michelassi 1 collaboration

Juli Bollinger 1 collaboration

Elizabeth May 1 collaboration

Debra Mathews 1 collaboration

Jeremy Sugarman 1 collaboration

Rafiq Sarker 1 collaboration

ChunYan Ye 1 collaboration

G McNamara 1 collaboration

Shang JuiTsai 1 collaboration

Andrew Karaba 1 collaboration

Jaiprasath Sachithanandhan 1 collaboration

Andy Pekosz 1 collaboration

Steven Gould 1 collaboration

Tifany Chu 1 collaboration

Pattareeya Yottasan 1 collaboration

Livia de Souza Goncalves 1 collaboration

Apurva A Oak 1 collaboration

Ming Tse 1 collaboration

Tianhao Bi 1 collaboration