Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling: IAFs disrupt colon epithelium via PGE2-EP4.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
28 Sep 2023
Historique:
medline: 9 10 2023
pubmed: 9 10 2023
entrez: 9 10 2023
Statut: epublish

Résumé

Inflammation-associated fibroblasts (IAFs) are associated with the progression and drug resistance of chronic inflammatory diseases such as inflammatory bowel disease (IBD), but their direct impact on epithelial function and architecture is unknown. In this study, we developed an

Identifiants

DOI: 10.1101/2023.09.28.560060 PMID: 37808771 PMC: PMC10557697
pubmed: 37808771
doi: 10.1101/2023.09.28.560060
pmc: PMC10557697
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : T32 GM136577
Pays : United States

Déclaration de conflit d'intérêts

Competing interests: Authors declare that they have no competing interests.

Auteurs

Yi Dong (Y)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Blake A Johnson (BA)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Linhao Ruan (L)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Maged Zeineldin (M)

Department of Pathology, Division of GI/Liver Pathology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Albert Z Liu (AZ)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Sumana Raychaudhuri (S)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Ian Chiu (I)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Jin Zhu (J)

Mechanobiology Institute and Department of Biological Sciences, National University of Singapore; Singapore.

Barbara Smith (B)

Microscope Facility, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Nan Zhao (N)

Institute for Nanobiotechnology, Johns Hopkins University; Baltimore, Maryland, 21218, U.S.A.

Peter Searson (P)

Institute for Nanobiotechnology, Johns Hopkins University; Baltimore, Maryland, 21218, U.S.A.
Department of Materials Science and Engineering, Johns Hopkins University; Baltimore, MD, 21218, U.S.A.

Shigeki Watanabe (S)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Mark Donowitz (M)

Department of Medicine, Division of Gastroenterology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Department of Physiology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Tatianna C Larman (TC)

Department of Pathology, Division of GI/Liver Pathology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.

Rong Li (R)

Department of Cell Biology, Johns Hopkins School of Medicine; Baltimore, MD, 21205, U.S.A.
Mechanobiology Institute and Department of Biological Sciences, National University of Singapore; Singapore.
Department of Biological Sciences, National University of Singapore; Singapore.

Classifications MeSH