Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2.
ACE2
SARS-CoV-2
bile acid
farnesoid X receptor
intestinal epithelium
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
medline:
12
10
2023
pubmed:
12
9
2023
entrez:
12
9
2023
Statut:
ppublish
Résumé
Intestinal inflammation and diarrhea are often associated with SARS-CoV-2 infection. The angiotensin converting enzyme 2 (ACE2) receptor plays a key role in SARS-CoV-2 pathogenesis, facilitating entry of the virus into epithelial cells, while also regulating mucosal inflammatory responses. Here, we investigated roles for the nuclear bile acid receptor farnesoid X receptor (FXR) in regulating ACE2 expression and virally mediated inflammatory responses in intestinal epithelia. Human colonic or ileal enteroids and cultured T
Identifiants
pubmed: 37697930
doi: 10.1152/ajpgi.00099.2023
doi:
Substances chimiques
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Cytokines
0
Interleukin-6
0
RNA, Messenger
0
farnesoid X-activated receptor
0C5V0MRU6P
Receptors, Cytoplasmic and Nuclear
0
ACE2 protein, human
EC 3.4.17.23
Banques de données
figshare
['10.6084/m9.figshare.24053331']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
G446-G452Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK089502
Pays : United States