Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.

Animals Cell Line Cells, Cultured Chenodeoxycholic Acid / toxicity Chlorides / metabolism Cystic Fibrosis Transmembrane Conductance Regulator / antagonists & inhibitors Diarrhea / drug therapy Female Humans Intestinal Mucosa / drug effects Intestinal Secretions / metabolism Mice Oxazines / pharmacology Pyrimidinones / pharmacology Pyrroles / pharmacology Rats Rats, Sprague-Dawley
BAD CFTR inhibitor chloride channel cystic fibrosis intestinal fluid secretion

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
10 2019
Historique:
pubmed: 4 7 2019
medline: 2 6 2020
entrez: 4 7 2019
Statut: ppublish

Résumé

Bile acid diarrhea (BAD) is common with ileal resection, Crohn's disease, and diarrhea-predominant irritable bowel syndrome. Here, we demonstrate the efficacy of cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor (

Identifiants

DOI: 10.1096/fj.201901166R PMID: 31268738 PMC: PMC6766649
pubmed: 31268738
doi: 10.1096/fj.201901166R
pmc: PMC6766649
doi:

Substances chimiques

(R)-BPO-27 0
Chlorides 0
Oxazines 0
Pyrimidinones 0
Pyrroles 0
Chenodeoxycholic Acid 0GEI24LG0J
Cystic Fibrosis Transmembrane Conductance Regulator 126880-72-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10924-10934

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK072517
Pays : United States

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Auteurs

Tianying Duan (T)

Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
Department of Physiology, University of California-San Francisco, San Francisco, California, USA.
Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, China.

Onur Cil (O)

Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
Department of Pediatrics, University of California-San Francisco, San Francisco, California, USA.

C Ming Tse (CM)

Gastroenterology Division, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Rafiquel Sarker (R)

Gastroenterology Division, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Ruxian Lin (R)

Gastroenterology Division, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gastroenterology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Mark Donowitz (M)

Gastroenterology Division, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gastroenterology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Alan S Verkman (AS)

Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
Department of Physiology, University of California-San Francisco, San Francisco, California, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Cellules › Cellules cultivées › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide désoxycholique › Chénodiol › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Protéines associées à la multirésistance aux médicaments › Protéine CFTR › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Diarrhée › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Sécrétions intestinales › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Inhibition of CFTR-mediated intestinal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Inhibition of CFTR-mediated intestinal...