Urinary tract infections in cystic fibrosis patients.
Antibiotic resistance
Cystic fibrosis
Cystitis
Urinary tract infection
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ISSN: 1873-5010
Titre abrégé: J Cyst Fibros
Pays: Netherlands
ID NLM: 101128966
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
02
03
2021
revised:
22
06
2021
accepted:
07
07
2021
pubmed:
1
8
2021
medline:
3
3
2022
entrez:
31
7
2021
Statut:
ppublish
Résumé
Improved understanding of non-respiratory infections in cystic fibrosis (CF) patients will be vital to sustaining the increased life span of these patients. To date, there has not been a published report of urinary tract infections (UTIs) in CF patients. We performed a retrospective chart review at a major academic medical center during 2010-2020 to determine the features of UTIs in 826 CF patients. We identified 108 UTI episodes during this period. Diabetes, distal intestinal obstruction syndrome (DIOS), and nephrolithiasis were correlated with increased risk of UTIs. UTIs in CF patients were less likely to be caused by Gram-negative rods compared to non-CF patients and more likely to be caused by Enterococcus faecalis. The unique features of UTIs in CF patients highlight the importance of investigating non-respiratory infections to ensure appropriate treatment.
Identifiants
pubmed: 34330649
pii: S1569-1993(21)01303-5
doi: 10.1016/j.jcf.2021.07.005
pmc: PMC9627942
mid: NIHMS1843320
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1-e4Subventions
Organisme : NIDDK NIH HHS
ID : P20 DK123967
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors declare that they have no conflicts of interest.
Références
J Cyst Fibros. 2017 Nov;16(6):647-648
pubmed: 29150009
J Mol Biol. 2020 Feb 14;432(4):786-804
pubmed: 31794727
J Am Soc Nephrol. 2020 Aug;31(8):1711-1727
pubmed: 32703846
N Engl J Med. 1996 Aug 15;335(7):468-74
pubmed: 8672152
Sci Rep. 2019 Dec 9;9(1):18593
pubmed: 31819107
Clin J Am Soc Nephrol. 2009 May;4(5):921-8
pubmed: 19406970
PLoS One. 2018 Jun 22;13(6):e0198457
pubmed: 29933382
Respirology. 2018 Jan;23(1):46-54
pubmed: 28718995
Pediatr Pulmonol. 2016 Oct;51(S44):S35-S44
pubmed: 27662102
Microbiol Spectr. 2016 Apr;4(2):
pubmed: 27227294
J Pediatr. 2017 Feb;181S:S4-S15.e1
pubmed: 28129811
Biophys Rev. 2009 Mar;1(1):3-12
pubmed: 28510151
Ann Epidemiol. 2000 Nov;10(8):509-15
pubmed: 11118930
J Transl Med. 2019 Nov 25;17(1):388
pubmed: 31767021
Presse Med. 2017 Jun;46(6 Pt 2):e125-e138
pubmed: 28554721
Infect Dis Clin North Am. 2014 Mar;28(1):1-13
pubmed: 24484571
Nat Rev Urol. 2017 May;14(5):296-310
pubmed: 28248946
J Cyst Fibros. 2019 Jul;18(4):507-515
pubmed: 30477895
BMC Microbiol. 2017 Mar 9;17(1):58
pubmed: 28279152
Clin Pharmacol Ther. 2008 Sep;84(3):362-9
pubmed: 18500243
Glob Pediatr Health. 2017 Nov 28;4:2333794X17743424
pubmed: 29226186
J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):38-42
pubmed: 19525866
Pediatr Diabetes. 2018 Oct;19 Suppl 27:64-74
pubmed: 30094886