Recent updates on immunological, pharmacological, and alternative approaches to combat COVID-19.
Antiviral
COVID-19
Convalescent plasma therapy
Corona virus
Vaccine
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
22
05
2021
accepted:
29
06
2021
pubmed:
1
8
2021
medline:
21
10
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
The pandemic coronavirus disease 2019 (COVID-19) is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is mainly transmitted via the inhalation route and characterized by fever, coughing and shortness of breath. COVID-19 affects all age groups with no single cure. The drug discovery, manufacturing, and safety studies require extensive time and sources and, therefore, struggled to match the exponential spread of COVID-19. Yet, various repurposed drugs (antivirals, immune-modulators, nucleotide analogues), and convalescent plasma therapy have been authorized for emergency use against COVID-19 by Food and Drug Administration under certain limits and conditions. The discovery of vaccine is the biggest milestone achieved during the current pandemic era. About nine vaccines were developed for human use with varying claims of efficacy. The rapid emergence of mutations in SARS-CoV-2, suspected adverse drug reactions of current therapies in special population groups and limited availability of drugs in developing countries necessitate the development of more efficacious, safe and cheap drugs/vaccines for treatment and prevention of COVID-19. Keeping in view these limitations, the current review provides an update on the efficacy and safety of the repurposed, and natural drugs to treat COVID-19 as well as the vaccines used for its prophylaxis.
Identifiants
pubmed: 34331179
doi: 10.1007/s10787-021-00850-7
pii: 10.1007/s10787-021-00850-7
pmc: PMC8324454
doi:
Substances chimiques
Antiviral Agents
0
Biological Products
0
COVID-19 Vaccines
0
Immunologic Factors
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1331-1346Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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