Multi-inflammatory syndrome and Kawasaki disease in children during the COVID-19 pandemic: A nationwide register-based study and time series analysis.
Kawasaki disease
epidemiology
multi-inflammatory syndrome in children
social distancing
transmissible microbes
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
26
07
2021
received:
14
05
2021
accepted:
28
07
2021
pubmed:
1
8
2021
medline:
28
10
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
We investigated whether the ongoing COVID-19 pandemic was associated with the occurrence of Kawasaki disease or with multi-inflammatory syndrome in children (MIS-C). This national Finnish register-based study was based on laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, MIS-C and Kawasaki disease cases. We performed a time series analysis on the occurrence of Kawasaki disease in 2016-2020. In 2020, there were 5170 laboratory-confirmed COVID-19 cases in children under 18 years of age and five fulfilled the MIS-C case definition. The occurrence of MIS-C was 0.97 per 1000 (95% confidence interval: 0.31-2.26) laboratory-confirmed SARS-CoV-2 infections in children. Our time series analysis showed that Kawasaki disease cases decreased during the COVID-19 pandemic. The seasonally adjusted incidence rate ratio was 0.49 (95% confidence interval: 0.32-0.74) when it was compared to pre-pandemic levels. This coincided with a reduced occurrence of respiratory infections, due to social distancing in the population. This nationwide register-based study found that MIS-C was a rare complication of the SARS-CoV-2 infection. The occurrence of Kawasaki disease and respiratory infections decreased during the pandemic. This suggests that transmissible microbes may play an important role in Kawasaki disease and social distancing may have a protective effect.
Identifiants
pubmed: 34331326
doi: 10.1111/apa.16051
pmc: PMC8444808
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3063-3068Informations de copyright
© 2021 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
Références
Acta Paediatr. 2021 Mar;110(3):937-938
pubmed: 33125767
PLoS One. 2013 Sep 18;8(9):e74529
pubmed: 24058585
Lancet. 2020 May 23;395(10237):1607-1608
pubmed: 32386565
Acta Paediatr. 2021 Nov;110(11):3063-3068
pubmed: 34331326
Pediatrics. 2021 Feb;147(2):
pubmed: 33234669
J Pediatr. 2020 Aug;223:199-203.e1
pubmed: 32405091
JAMA. 2020 Apr 7;323(13):1313-1314
pubmed: 32058570
N Engl J Med. 2020 Jul 23;383(4):334-346
pubmed: 32598831
J Infect Dis. 2005 Feb 15;191(4):499-502
pubmed: 15655771
Int J Epidemiol. 2017 Feb 1;46(1):348-355
pubmed: 27283160
JAMA Netw Open. 2021 Apr 1;4(4):e214475
pubmed: 33822065
BMJ. 2020 Jun 3;369:m2094
pubmed: 32493739
N Engl J Med. 2018 May 24;378(21):2048-2049
pubmed: 29791820
EClinicalMedicine. 2021 Apr;34:100807
pubmed: 33817612
Pediatr Infect Dis J. 2020 Dec;39(12):e423-e427
pubmed: 32773660
Epidemiology. 2005 Mar;16(2):220-5
pubmed: 15703537
Lancet. 2020 Jun 6;395(10239):1771-1778
pubmed: 32410760
JAMA. 2021 Mar 16;325(11):1074-1087
pubmed: 33625505
JAMA Pediatr. 2021 Aug 1;175(8):837-845
pubmed: 33821923
N Engl J Med. 2020 Jul 23;383(4):347-358
pubmed: 32598830
J Pediatric Infect Dis Soc. 2021 Aug 14;10(6):742-744
pubmed: 33755140
Lancet Child Adolesc Health. 2020 Sep;4(9):662-668
pubmed: 32622376
Circulation. 2020 Aug 4;142(5):429-436
pubmed: 32418446
J Pediatr. 2020 Oct;225:23-29.e2
pubmed: 32454114