Antidiabetic Properties of Curcumin: Insights on New Mechanisms.

Anti-Inflammatory Agents / pharmacology Curcumin / pharmacology Humans Hypoglycemic Agents / pharmacology PPAR gamma Plant Extracts / pharmacology Signal Transduction
Alpha-amylase Alpha-glycosidase Curcumin Diabetes Dipeptidyl peptidase-4 Glucagon-like peptide-1 Glucose transporter PPARγ

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2021
Historique:
entrez: 31 7 2021
pubmed: 1 8 2021
medline: 4 8 2021
Statut: ppublish

Résumé

Plant extracts have been used to treat a wide range of human diseases. Curcumin, a bioactive polyphenol derived from Curcuma longa L., exhibits therapeutic effects against diabetes while only negligible adverse effects have been observed. Antioxidant and anti-inflammatory properties of curcumin are the main and well-recognized pharmacological effects that might explain its antidiabetic effects. Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARγ). Recent findings from in vitro and in vivo studies on novel signaling pathways involved in the potential beneficial effects of curcumin for the treatment of diabetes are discussed in this review.

Identifiants

DOI: 10.1007/978-3-030-56153-6_9 PMID: 34331689
pubmed: 34331689
doi: 10.1007/978-3-030-56153-6_9
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Hypoglycemic Agents 0
PPAR gamma 0
Plant Extracts 0
Curcumin IT942ZTH98

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

151-164

Informations de copyright

© 2021. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Elahe Mohammadi (E)

Student Research Committee, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

Behzad Behnam (B)

Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran. behnamb@kmu.ac.ir.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. behnamb@kmu.ac.ir.
Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran. behnamb@kmu.ac.ir.

Reza Mohammadinejad (R)

Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Paul C Guest (PC)

Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.

Luis E Simental-Mendía (LE)

Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.

Amirhossein Sahebkar (A)

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.
Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. sahebkara@mums.ac.ir.
Halal Research Center of IRI, FDA, Tehran, Iran. sahebkara@mums.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Antidiabetic Properties of Curcumin: Insights...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Antidiabetic Properties of Curcumin: Insights...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antidiabetic Properties of Curcumin: Insights...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Antidiabetic Properties of Curcumin: Insights...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › Antidiabetic Properties of Curcumin: Insights...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Antidiabetic Properties of Curcumin: Insights...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Antidiabetic Properties of Curcumin: Insights...