Application of ultra-sensitive GC-QqQ-MS/MS (MRM) method for the determination of diclofenac in whole blood samples without derivatization.
Diclofenac
GC–MS/MS
MRM mode
Triple quadrupole
Whole blood
Journal
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554
Informations de publication
Date de publication:
01 Aug 2021
01 Aug 2021
Historique:
received:
26
04
2021
revised:
13
06
2021
accepted:
11
07
2021
pubmed:
1
8
2021
medline:
11
11
2021
entrez:
31
7
2021
Statut:
ppublish
Résumé
Diclofenac is one of the most frequently prescribed nonsteroidal anti-inflammatory drugs (NSAID) worldwide. Although it is considered a relatively safe drug, it exhibits high toxicity to some animal populations (e.g., raptors). An ultra-sensitive gas chromatography method, coupled with tandem mass spectrometry (GC-QqQ-MS/MS) with an electron impact (EI) ionization source for diclofenac determination in whole blood samples without a derivatization procedure, was developed and fully validated. Diclofenac-d
Identifiants
pubmed: 34332200
pii: S1570-0232(21)00341-X
doi: 10.1016/j.jchromb.2021.122860
pii:
doi:
Substances chimiques
Diclofenac
144O8QL0L1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122860Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.