Mobilisation of plasmid-mediated bla

Ceftazidime / pharmacology Drug Resistance, Multiple, Bacterial / genetics Genomic Islands Humans Plasmids / genetics Proteus Infections Proteus mirabilis / genetics
Cassette array Class 1 integron IncP1 PGI1 SGI1 bla(VEB-1)

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
12 2021
Historique:
received: 02 12 2019
revised: 31 05 2021
accepted: 11 07 2021
pubmed: 2 8 2021
medline: 31 12 2021
entrez: 1 8 2021
Statut: ppublish

Résumé

We sought to integrate a VEB-1-encoding gene cassette into the integron of the MDR region of genomic islands (GIs) harboured by Proteus mirabilis strains after antibiotic exposure. An IncP1 plasmid from Achromobacter xylosoxidans carrying the cassette array dfrA14-bla Circular intermediates were detected for dfrA14 and bla Homologous recombination of gene cassettes conferring resistance to clinically important antibiotics may occur under antibiotic pressure between an integron located on a plasmid and a co-resident GI. This feature participates in the acquisition, maintenance and spread of antibiotic resistance genes.

Identifiants

DOI: 10.1016/j.jgar.2021.07.011 PMID: 34333164
pubmed: 34333164
pii: S2213-7165(21)00181-8
doi: 10.1016/j.jgar.2021.07.011
pii:
doi:

Substances chimiques

Ceftazidime 9M416Z9QNR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

26-30

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Eliane Siebor (E)

Laboratory of Bacteriology, University Hospital of Dijon, Plateau technique de Biologie, BP 37013, 21070 Dijon Cedex, France; and UMR 6249, CNRS Chrono-environnement, Université de Bourgogne Franche-Comté, 25000, Besançon, France.

Claire de Curraize (C)

Laboratory of Bacteriology, University Hospital of Dijon, Plateau technique de Biologie, BP 37013, 21070 Dijon Cedex, France; and UMR 6249, CNRS Chrono-environnement, Université de Bourgogne Franche-Comté, 25000, Besançon, France.

Veronique Varin (V)

Laboratory of Bacteriology, University Hospital of Dijon, Plateau technique de Biologie, BP 37013, 21070 Dijon Cedex, France; and UMR 6249, CNRS Chrono-environnement, Université de Bourgogne Franche-Comté, 25000, Besançon, France.

Arnaud Magallon (A)

Laboratory of Bacteriology, University Hospital of Dijon, Plateau technique de Biologie, BP 37013, 21070 Dijon Cedex, France; and UMR 6249, CNRS Chrono-environnement, Université de Bourgogne Franche-Comté, 25000, Besançon, France.

Catherine Neuwirth (C)

Laboratory of Bacteriology, University Hospital of Dijon, Plateau technique de Biologie, BP 37013, 21070 Dijon Cedex, France; and UMR 6249, CNRS Chrono-environnement, Université de Bourgogne Franche-Comté, 25000, Besançon, France. Electronic address: catherine.neuwirth@chu-dijon.fr.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfaloridine › Ceftazidime › Mobilisation of plasmid-mediated bla
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Mobilisation of plasmid-mediated bla
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Ilots génomiques › Mobilisation of plasmid-mediated bla
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mobilisation of plasmid-mediated bla
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Plasmides › Mobilisation of plasmid-mediated bla
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Proteus › Mobilisation of plasmid-mediated bla
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Proteus › Proteus mirabilis › Mobilisation of plasmid-mediated bla