SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis.
Apoptosis
/ genetics
Cell Line, Tumor
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Colorectal Neoplasms
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Kruppel-Like Transcription Factors
/ metabolism
Microfilament Proteins
/ metabolism
Signal Transduction
Tumor Hypoxia
/ genetics
YAP-Signaling Proteins
/ metabolism
Colorectal cancer (CRC)
Epithelial-mesenchymal transformation (EMT)
Kruppel like factor 5 (KLF5)
Synapsopoprotein 2 (SYNPO2)
YAP
Journal
Tissue & cell
ISSN: 1532-3072
Titre abrégé: Tissue Cell
Pays: Scotland
ID NLM: 0214745
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
16
04
2021
revised:
22
07
2021
accepted:
23
07
2021
pubmed:
2
8
2021
medline:
3
3
2022
entrez:
1
8
2021
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is one of the most common tumors that has a high incidence worldwide. Targeted therapy for CRC has received much attention recently. It is still necessary to develop novel and promising therapeutic targets to improve the prognosis. SYNPO2, also known as synapsopoprotein 2 or myopod, encodes actin binding proteins and has been characterized as a tumor suppressor for aggressive cancers. SYNPO2 has been reported to inhibit the activity of YAP/TAZ. However, whether SYNPO2 could regulate the progression of CRC through the YAP/YAZ signaling pathway remains unclear. Herein, it was found that the expression of SYNPO2 was low in hypoxia-exposed CRC cells, consistent with the data from TCGA database. SYNPO2 inhibited the growth of CRC cells upon hypoxia treatment and promoted the cell apoptosis. Additionally, SYNPO2 inhibited the migration and epithelial-mesenchymal transformation (EMT) CRC cell upon hypoxia treatment. Mechanically, the results demonstrated that SYNPO2 suppressed hypoxia-induced progression of CRC by regulating YAP-Kruppel like factor 5 (KLF5) axis. Therefore, SYNPO2 can serve as a promising therapeutic target for CRC treatment.
Identifiants
pubmed: 34333382
pii: S0040-8166(21)00114-2
doi: 10.1016/j.tice.2021.101598
pii:
doi:
Substances chimiques
KLF5 protein, human
0
Kruppel-Like Transcription Factors
0
Microfilament Proteins
0
SYNPO2 protein, human
0
YAP-Signaling Proteins
0
YAP1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101598Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.