Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models.
Animals
B-Lymphocytes
/ immunology
Biomarkers, Tumor
Disease Models, Animal
Disease Susceptibility
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Germinal Center
/ immunology
Humans
Lymphoma, B-Cell
/ etiology
Mice
Mice, Transgenic
Monitoring, Immunologic
Translocation, Genetic
diffuse large B cell lymphoma (DLBCL)
epigenetic modifier mutations
follicular lymphoma (FL)
genetically engineered mouse (GEMs)
germinal center (GC)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
03
2021
accepted:
12
05
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Lymphomas are cancers deriving from lymphocytes, arising preferentially in secondary lymphoid organs, and represent the 6th cancer worldwide and the most frequent blood cancer. The majority of B cell Non-Hodgkin lymphomas (B-NHL) develop from germinal center (GC) experienced mature B cells. GCs are transient structures that form in lymphoid organs in response to antigen exposure of naive B cells, and where B cell receptor (BCR) affinity maturation occurs to promote B cell differentiation into memory B and plasma cells producing high-affinity antibodies. Genomic instability associated with the somatic hypermutation (SHM) and class-switch recombination (CSR) processes during GC transit enhance susceptibility to malignant transformation. Most B cell differentiation steps in the GC are at the origin of frequent B cell malignant entities, namely Follicular Lymphoma (FL) and GCB diffuse large B cell lymphomas (GCB-DLBCL). Over the past decade, large sequencing efforts have provided a great boost in the identification of candidate oncogenes and tumor suppressors involved in FL and DLBCL oncogenesis. Mouse models have been instrumental to accurately mimic
Identifiants
pubmed: 34335584
doi: 10.3389/fimmu.2021.683597
pmc: PMC8323519
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
683597Informations de copyright
Copyright © 2021 Mossadegh-Keller, Brisou, Beyou, Nadel and Roulland.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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