FRONTotemporal dementia Incidence European Research Study-FRONTIERS: Rationale and design.
epidemiology
frontotemporal dementia
frontotemporal lobar degeneration
incidence
rare diseases
registry
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
22
05
2021
received:
01
02
2021
accepted:
09
06
2021
pubmed:
3
8
2021
medline:
26
4
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
The incidence of Frontotemporal Lobar Degeneration (FTLD)-related disorders and their characteristics are not well known. The "FRONTotemporal dementia Incidence European Research Study" (FRONTIERS) is designed to fill this gap. FRONTIERS is a European prospective, observational population study based on multinational registries. FRONTIERS comprises 11 tertiary referral centers across Europe with long-lasting experience in FTLD-related disorders and comprehensive regional referral networks, enabling incidence estimation over well-defined geographical areas. The primary endpoints are (1) the incidence of FTLD-related disorders across Europe; (2) geographic trends of FTLD-related disorders; (3) the distribution of FTLD phenotypes in different populations and ethnicities in Europe; (4) inheritance of FTLD-related disorders, including the frequencies of monogenic FTLD as compared to overall disease burden; and (5) implementation of data banking for clinical and biological material. FRONTIERS will improve the understanding of FTLD-related disorders and their epidemiology, promoting appropriate public health service policies and treatment strategies.
Identifiants
pubmed: 34338439
doi: 10.1002/alz.12414
pmc: PMC9291221
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
498-506Subventions
Organisme : Medical Research Council
ID : MR/M009041/1
Pays : United Kingdom
Organisme : Department of Health
ID : BRC-1215-20014
Pays : United Kingdom
Organisme : Medical Research Council
ID : G101400
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
J Neurol Neurosurg Psychiatry. 2017 Jul;88(7):557-563
pubmed: 28285264
Neuroepidemiology. 2019;52(1-2):93-103
pubmed: 30602169
Acta Neuropathol. 2015 Apr;129(4):469-91
pubmed: 25549971
Ann Neurol. 2013 Nov;74(5):699-708
pubmed: 23836460
Curr Opin Neurobiol. 2020 Apr;61:29-39
pubmed: 31838254
Parkinsonism Relat Disord. 2020 Oct;79:121-126
pubmed: 32947108
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Int Rev Psychiatry. 2013 Apr;25(2):130-7
pubmed: 23611343
Neurology. 2017 Jun 13;88(24):2321-2329
pubmed: 28515268
Acta Neuropathol. 2010 Jan;119(1):1-4
pubmed: 19924424
Neurology. 2016 May 3;86(18):1736-43
pubmed: 27037234
Lancet Neurol. 2020 Feb;19(2):145-156
pubmed: 31810826
Neurology. 2004 Feb 10;62(3):506-8
pubmed: 14872045
Brain. 2003 Sep;126(Pt 9):2016-22
pubmed: 12876142
Mov Disord. 2017 Jun;32(6):853-864
pubmed: 28467028
Alzheimers Dement. 2020 Jan;16(1):106-117
pubmed: 31914218
Brain. 2007 Jun;130(Pt 6):1552-65
pubmed: 17405767
J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):157-164
pubmed: 30309882
Neuroepidemiology. 2020;54(2):114-122
pubmed: 31910416
Brain. 2020 May 1;143(5):1555-1571
pubmed: 32438414
Brain. 2011 Sep;134(Pt 9):2456-77
pubmed: 21810890
Int J Epidemiol. 2018 Aug 1;47(4):1343-1354
pubmed: 29939274
Acta Neuropathol. 2014 Sep;128(3):423-37
pubmed: 24916269
Alzheimer Dis Assoc Disord. 2011 Oct-Dec;25(4):341-4
pubmed: 21399481
Neurology. 2019 May 14;92(20):e2355-e2363
pubmed: 30979859
Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1150-7
pubmed: 17071060
Brain. 2005 Sep;128(Pt 9):1996-2005
pubmed: 16033782
Neurology. 2013 Jan 29;80(5):496-503
pubmed: 23359374
Epidemiol Rev. 1995;17(2):243-64
pubmed: 8654510
Brain. 2011 Sep;134(Pt 9):2565-81
pubmed: 21908872
J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1206-9
pubmed: 12933919
J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):125
pubmed: 31672700
Front Aging Neurosci. 2015 Sep 01;7:171
pubmed: 26388768
Alzheimers Dement. 2021 Jan;17(1):81-88
pubmed: 32914938
J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):6-11
pubmed: 18079297
Alzheimers Dement. 2022 Mar;18(3):498-506
pubmed: 34338439
Acta Neuropathol. 2014 Mar;127(3):391-6
pubmed: 24496499
J Clin Epidemiol. 2000 Oct;53(10):1025-9
pubmed: 11027935
Brain. 2017 Dec 1;140(12):3329-3345
pubmed: 29053860
Alzheimers Dement. 2020 Mar;16(3):482-490
pubmed: 31784373
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):867-71
pubmed: 12810769