Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore.
Animals
Antibodies, Monoclonal
/ chemistry
Boron Compounds
/ chemical synthesis
Breast Neoplasms
/ diagnostic imaging
Dose-Response Relationship, Drug
Drug Development
Female
Fluorescent Dyes
/ chemical synthesis
Hep G2 Cells
Humans
Mammary Neoplasms, Experimental
/ diagnostic imaging
Mice
Mice, Nude
Molecular Structure
Optical Imaging
Solubility
Structure-Activity Relationship
Tomography, Emission-Computed, Single-Photon
Water
/ chemistry
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
12 08 2021
12 08 2021
Historique:
pubmed:
3
8
2021
medline:
25
2
2023
entrez:
2
8
2021
Statut:
ppublish
Résumé
A water-soluble fluorescent aza-BODIPY platform (Wazaby) was prepared and functionalized by a polyazamacrocycle agent and a bioconjugable arm. The resulting fluorescent derivative was characterized and bioconjugated onto a trastuzumab monoclonal antibody as a vector. After bioconjugation, the imaging agent appeared to be stable in serum (>72 h at 37 °C) and specifically labeled HER-2-positive breast tumors slices. The bioconjugate was radiolabeled with [
Identifiants
pubmed: 34338511
doi: 10.1021/acs.jmedchem.1c00450
doi:
Substances chimiques
Antibodies, Monoclonal
0
Boron Compounds
0
Fluorescent Dyes
0
azaBDPBA compound
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM