Evaluation of the Higher Order Structure of Biotherapeutics Embedded in Hydrogels for Bioprinting and Drug Release.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
17 08 2021
17 08 2021
Historique:
pubmed:
3
8
2021
medline:
1
9
2021
entrez:
2
8
2021
Statut:
ppublish
Résumé
Biocompatible hydrogels for tissue regeneration/replacement and drug release with specific architectures can be obtained by three-dimensional bioprinting techniques. The preservation of the higher order structure of the proteins embedded in the hydrogels as drugs or modulators is critical for their biological activity. Solution nuclear magnetic resonance (NMR) experiments are currently used to investigate the higher order structure of biotherapeutics in comparability, similarity, and stability studies. However, the size of pores in the gel, protein-matrix interactions, and the size of the embedded proteins often prevent the use of this methodology. The recent advancements of solid-state NMR allow for the comparison of the higher order structure of the matrix-embedded and free isotopically enriched proteins, allowing for the evaluation of the functionality of the material in several steps of hydrogel development. Moreover, the structural information at atomic detail on the matrix-protein interactions paves the way for a structure-based design of these biomaterials.
Identifiants
pubmed: 34339178
doi: 10.1021/acs.analchem.1c01850
pmc: PMC8382223
doi:
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11208-11214Références
J Biomol NMR. 2013 Oct;57(2):155-66
pubmed: 23990200
Pharm Res. 2016 Feb;33(2):462-75
pubmed: 26453189
J Magn Reson. 2020 Feb;311:106680
pubmed: 31951864
Phys Chem Chem Phys. 2018 May 9;20(18):12719-12726
pubmed: 29697113
Biomacromolecules. 2017 Feb 13;18(2):316-330
pubmed: 28027640
J Biomol NMR. 2000 Apr;16(4):329-37
pubmed: 10826884
Biomaterials. 2016 Nov;106:58-68
pubmed: 27552316
J Biol Chem. 2020 Jul 24;295(30):10446-10455
pubmed: 32518163
Angew Chem Int Ed Engl. 2021 Jun 1;60(23):12847-12851
pubmed: 33750007
J Biomol NMR. 2019 Sep;73(8-9):451-460
pubmed: 31407201
Nat Commun. 2020 Jul 31;11(1):3859
pubmed: 32737298
Drug Discov Today. 2019 Aug;24(8):1470-1482
pubmed: 31202673
Viruses. 2020 Sep 24;12(10):
pubmed: 32987909
Biomater Res. 2019 Feb 6;23:3
pubmed: 30774971
Cell Mol Life Sci. 2001 Sep;58(10):1491-521
pubmed: 11693529
J Mech Behav Biomed Mater. 2018 Mar;79:150-157
pubmed: 29304429
Physiol Res. 2018 Oct 30;67(Suppl 2):S319-S334
pubmed: 30379553
NPJ Vaccines. 2019 May 28;4:20
pubmed: 31149351
Amyloid. 2003 Sep;10(3):160-84
pubmed: 14640030
Biomed Microdevices. 2011 Dec;13(6):983-93
pubmed: 21773726
Biomolecules. 2019 Aug 14;9(8):
pubmed: 31416261
Sci Rep. 2017 Dec 20;7(1):17934
pubmed: 29263419
Chemistry. 2019 Feb 6;25(8):1984-1991
pubmed: 30462348
Nat Struct Mol Biol. 2020 Sep;27(9):863-869
pubmed: 32901160
Chem Rev. 2012 May 9;112(5):2853-88
pubmed: 22360637
J Biomol NMR. 2000 Dec;18(4):303-9
pubmed: 11200524
Chemistry. 2016 Jan 4;22(1):425-32
pubmed: 26625942
J Biomol NMR. 2018 Dec;72(3-4):149-161
pubmed: 30483914
Biomaterials. 2005 Jan;26(2):125-35
pubmed: 15207459
Chembiochem. 2010 Jul 26;11(11):1543-51
pubmed: 20572250
Sci Rep. 2016 Apr 19;6:24474
pubmed: 27091175
Biomacromolecules. 2020 Apr 13;21(4):1327-1350
pubmed: 32078290
Neurology. 1986 Jul;36(7):900-11
pubmed: 3714052
Anal Biochem. 2006 Apr 15;351(2):282-9
pubmed: 16460655
PLoS One. 2013 Aug 19;8(8):e72610
pubmed: 23977328
Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14997-15001
pubmed: 29024352
Biofabrication. 2016 Sep 16;8(3):035020
pubmed: 27634915
J Phys Chem B. 2019 Jun 20;123(24):5048-5058
pubmed: 31125232
Nat Rev Cancer. 2016 Jan;16(1):56-66
pubmed: 26694936
Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2446-9
pubmed: 26756539
J Biomed Mater Res A. 2013 May;101(5):1255-64
pubmed: 23015540
J Phys Chem B. 2017 Aug 31;121(34):8094-8101
pubmed: 28762736
J Biomed Mater Res B Appl Biomater. 2010 Oct;95(1):110-7
pubmed: 20725955
Solid State Nucl Magn Reson. 2019 Oct;102:2-11
pubmed: 31216494
J Magn Reson. 2015 Apr;253:60-70
pubmed: 25797005
Biofabrication. 2018 Jun 29;10(3):034106
pubmed: 29923501
Curr Protoc Protein Sci. 2020 Jun;100(1):e105
pubmed: 32407007
Sci Rep. 2016 Jun 09;6:27851
pubmed: 27279168
J Pept Sci. 2007 May;13(5):342-7
pubmed: 17436341
Biomaterials. 2010 Aug;31(24):6173-81
pubmed: 20546891
Int J Mol Sci. 2012;13(5):6102-16
pubmed: 22754352
J Pharm Biomed Anal. 2017 Jul 15;141:229-233
pubmed: 28454057
Drug Deliv. 2005 Nov-Dec;12(6):327-42
pubmed: 16253949
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:176-183
pubmed: 29684909
Chem Commun (Camb). 2014 Jan 14;50(4):421-3
pubmed: 24248259
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1469-1476
pubmed: 30889681
J Phys Chem B. 2012 Sep 27;116(38):11656-61
pubmed: 22953757
MAbs. 2019 Jan;11(1):94-105
pubmed: 30570405
Anal Chem. 2021 Jan 26;93(3):1377-1382
pubmed: 33377773
ACS Appl Mater Interfaces. 2017 Jul 19;9(28):24140-24147
pubmed: 28675028
Oncologist. 2020 Nov;25(11):e1725-e1731
pubmed: 32627928
Front Mol Biosci. 2020 Feb 21;7:17
pubmed: 32154263
J Am Soc Mass Spectrom. 2013 Jun;24(6):835-45
pubmed: 23483515
J Control Release. 2021 Jul 10;335:75-85
pubmed: 33971140
J Mater Chem B. 2014 Mar 21;2(11):1470-1482
pubmed: 32261366
Chemistry. 2020 Jul 22;26(41):8976-8982
pubmed: 32428253
Nat Biotechnol. 2016 Feb;34(2):139-41
pubmed: 26849514
Acta Biomater. 2014 Oct;10(10):4323-31
pubmed: 24998183
J Biomol NMR. 2015 Jan;61(1):7-20
pubmed: 25420598
Acta Biomater. 2020 Apr 1;106:114-123
pubmed: 32027992
Anal Chem. 2015 Apr 7;87(7):3556-61
pubmed: 25728213
Anal Chem. 2014 Mar 4;86(5):2657-64
pubmed: 24512515
Biomater Sci. 2013 Jul 4;1(7):763-773
pubmed: 32481829