Molecular basis for lipid recognition by the prostaglandin D

Crystallography, X-Ray / methods Humans Lipid Metabolism Molecular Dynamics Simulation Mutation Prostaglandin D2 / chemistry Protein Conformation Receptors, Immunologic / chemistry Receptors, Prostaglandin / chemistry
CRTH2 (DP2) MD simulations crystal structure lipid binding prostaglandin D2

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
10 08 2021
Historique:
entrez: 3 8 2021
pubmed: 4 8 2021
medline: 18 12 2021
Statut: ppublish

Résumé

Prostaglandin D

Identifiants

DOI: 10.1073/pnas.2102813118 PMID: 34341104 PMC: PMC8364189
pubmed: 34341104
pii: 2102813118
doi: 10.1073/pnas.2102813118
pmc: PMC8364189
pii:
doi:

Substances chimiques

Receptors, Immunologic 0
Receptors, Prostaglandin 0
Prostaglandin D2 RXY07S6CZ2
prostaglandin D2 receptor XZF106QU24

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM128641
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Heng Liu (H)

Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.

R N V Krishna Deepak (RNVK)

Bioinformatics Institute, Agency for Science, Technology and Research, Matrix 138671, Singapore.
ORCID: 0000-0001-6629-8450

Anna Shiriaeva (A)

Bridge Institute, University of Southern California Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089.
Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
ORCID: 0000-0002-4082-7884

Cornelius Gati (C)

Bridge Institute, University of Southern California Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089.
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.

Alexander Batyuk (A)

Linac Coherent Light Source, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025.
ORCID: 0000-0002-9393-2880

Hao Hu (H)

Department of Physics, Arizona State University, Tempe, AZ 85281.

Uwe Weierstall (U)

Department of Physics, Arizona State University, Tempe, AZ 85281.
ORCID: 0000-0002-3594-930X

Wei Liu (W)

Center for Applied Structural Discovery at the Biodesign Institute, Arizona State University, Tempe, AZ 85281.
School of Molecular Sciences, Arizona State University, Tempe, AZ 85281.

Lei Wang (L)

Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
ORCID: 0000-0002-3024-8627

Vadim Cherezov (V)

Bridge Institute, University of Southern California Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA 90089; chengzh@pitt.edu fanh@bii.a-star.edu.sg cherezov@usc.edu.
Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
ORCID: 0000-0002-5265-3914

Hao Fan (H)

Bioinformatics Institute, Agency for Science, Technology and Research, Matrix 138671, Singapore; chengzh@pitt.edu fanh@bii.a-star.edu.sg cherezov@usc.edu.

Cheng Zhang (C)

Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; chengzh@pitt.edu fanh@bii.a-star.edu.sg cherezov@usc.edu.
ORCID: 0000-0001-9042-4007

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines D › Prostaglandine D2 › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Molecular basis for lipid recognition by the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteur prostaglandine › Molecular basis for lipid recognition by the...