Prostate interventions in patients with mild haemophilia: Safe and feasible.

biopsy haemophilia A haemophilia B laser therapy prostate prostatectomy transurethral resection of prostate

Journal

Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916

Informations de publication

Date de publication:
Nov 2021
Historique:
revised: 15 07 2021
received: 26 04 2021
accepted: 16 07 2021
pubmed: 4 8 2021
medline: 11 11 2021
entrez: 3 8 2021
Statut: ppublish

Résumé

To date, there is no specific recommendation or evaluation of the morbidity of prostate surgery in patients with haemophilia (PWH) although this surgery is common and at high risk of bleeding. To assess the post-operative morbidity of benign prostate hyperplasia (BPH) surgeries and of oncological prostate interventions in patients with mild haemophilia A or B. We performed a monocentre, epidemiological, in real life study. Data were collected between 1 January, 1997 and 1 September, 2020 and focused on prostate biopsy, radical prostatectomy, prostate radiotherapy, simple prostatectomy, transurethral resection of prostate (TURP) and laser-vaporisation in patients with mild haemophilia A or B. Between 1 January, 1997 and 1 September, 2020, 51 interventions were performed on 30 patients with mild haemophilia. Haemophilia A represented 93.33% of the population and haemophilia B 6.67%. For prostate biopsies (n = 24), median length of hospitalisation was 4 days and only one patient needed a blood transfusion. No patient needed re-admission. For prostatectomy (n = 10), one patient presented with intra-operative and post-operative bleeding. Two patients required re-admission. The other patients did not present any significant haemorrhagic symptoms. For radiotherapy (n = 4), two patients presented a grade II complication (radiocystitis and radiorectitis). For BPH surgeries, during hospitalisation, laser-vaporisation (n = 5) was less haemorrhagic than TURP (n = 5) but after hospital discharge, 60% of patients presented a haemorrhagic complication with two readmissions and one surgical re-explorations. Performed in a specialised centre, prostate surgeries and interventions in patients with mild haemophilia is feasible with acceptable morbidity.

Identifiants

pubmed: 34342928
doi: 10.1111/hae.14388
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e659-e666

Informations de copyright

© 2021 John Wiley & Sons Ltd.

Références

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Auteurs

Benoit Mesnard (B)

Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.

Nicolas Drillaud (N)

Haemophilia Centre, Nantes University Hospital, Nantes, France.

Marianne Sigaud (M)

Haemophilia Centre, Nantes University Hospital, Nantes, France.

Gabriella Hakim (G)

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

Samuel Chelly (S)

Department of Urology, Angers University Hospital, Angers, France.

Catherine Ternisien (C)

Haemophilia Centre, Nantes University Hospital, Nantes, France.

Marc Fouassier (M)

Haemophilia Centre, Nantes University Hospital, Nantes, France.

Ismaël Chelghaf (I)

Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.

Stéphane De Vergie (S)

Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.

Marie-Aimée Perrouin Verbe (MA)

Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.

Jérôme Rigaud (J)

Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.

Arthur David (A)

Department of Radiology, Nantes University Hospital, Nantes, France.

Marc Trossaërt (M)

Haemophilia Centre, Nantes University Hospital, Nantes, France.

Julien Branchereau (J)

Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Centre de Recherche en Transplantation et Immunologie CRTI Inserm, Nantes University, Nantes, France.

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