Gut Microbiome and Serum Metabolome Alterations Associated with Isolated Dystonia.
16S rRNA
dystonia
gut microbiome
metagenomics
serum metabolome
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
25 08 2021
25 08 2021
Historique:
pubmed:
5
8
2021
medline:
14
1
2022
entrez:
4
8
2021
Statut:
ppublish
Résumé
Dystonia is a complex neurological movement disorder characterized by involuntary muscle contractions. Increasing studies implicate the microbiome as a possible key susceptibility factor for neurological disorders, but the relationship between the gut microbiota and dystonia remains poorly explored. Here, the gut microbiota of 57 patients with isolated dystonia and 27 age- and environment-matched healthy controls was analyzed by 16S rRNA gene amplicon sequencing. Further, integrative analysis of the gut microbiome and serum metabolome measured by high-performance liquid chromatography-mass spectrometry was performed. No difference in α-diversity was found, while β-diversity was significantly different, with a more heterogeneous community structure among dystonia patients than among controls. The most significant changes in dystonia highlighted an increase in
Identifiants
pubmed: 34346706
doi: 10.1128/mSphere.00283-21
pmc: PMC8386414
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0028321Références
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