Repeated nuclear translocations underlie photoreceptor positioning and lamination of the outer nuclear layer in the mammalian retina.
Actomyosin
/ metabolism
Animals
Cell Nucleus
/ metabolism
Dyneins
/ metabolism
Kinetics
Mice, Transgenic
Microtubules
/ metabolism
Myosin Type II
/ metabolism
Neurogenesis
Photoreceptor Cells, Vertebrate
/ metabolism
Polymerization
Protein Transport
Retina
/ metabolism
Retinal Cone Photoreceptor Cells
/ metabolism
Retinal Rod Photoreceptor Cells
/ metabolism
Synapses
/ metabolism
development
dynein
interkinetic nuclear migration
lamination
motor proteins
neuronal migration
retina
synaptogenesis
tissue differentiation
translocation
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
18
03
2019
revised:
19
11
2019
accepted:
09
07
2021
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
12
2
2022
Statut:
ppublish
Résumé
In development, almost all stratified neurons must migrate from their birthplace to the appropriate neural layer. Photoreceptors reside in the most apical layer of the retina, near their place of birth. Whether photoreceptors require migratory events for fine-positioning and/or retention within this layer is not well understood. Here, we show that photoreceptor nuclei of the developing mouse retina cyclically exhibit rapid, dynein-1-dependent translocation toward the apical surface, before moving more slowly in the basal direction, likely due to passive displacement by neighboring retinal nuclei. Attenuating dynein 1 function in rod photoreceptors results in their ectopic basal displacement into the outer plexiform layer and inner nuclear layer. Synapse formation is also compromised in these displaced cells. We propose that repeated, apically directed nuclear translocation events are necessary to ensure retention of post-mitotic photoreceptors within the emerging outer nuclear layer during retinogenesis, which is critical for correct neuronal lamination.
Identifiants
pubmed: 34348137
pii: S2211-1247(21)00884-6
doi: 10.1016/j.celrep.2021.109461
pmc: PMC8356022
pii:
doi:
Substances chimiques
Actomyosin
9013-26-7
Myosin Type II
EC 3.6.1.-
Dyneins
EC 3.6.4.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109461Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 082217
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J004553/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of interests The authors declare no competing interests
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