Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice.
Animals
Astrocytes
/ physiology
Brain Injuries
/ immunology
Cell Adhesion Molecules
/ genetics
Cells, Cultured
Cicatrix
/ immunology
Disease Models, Animal
Gliosis
Glycosaminoglycans
/ metabolism
Humans
Inflammation
/ immunology
Mice
Mice, Knockout
Neuroglia
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Astrocytes
Glial scar
Glycosaminoglycans and inflammation
TSG-6
Journal
BMC immunology
ISSN: 1471-2172
Titre abrégé: BMC Immunol
Pays: England
ID NLM: 100966980
Informations de publication
Date de publication:
04 08 2021
04 08 2021
Historique:
received:
21
04
2020
accepted:
09
07
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
29
1
2022
Statut:
epublish
Résumé
Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries. Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site. Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.
Sections du résumé
BACKGROUND
Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries.
RESULTS
Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site.
CONCLUSION
Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.
Identifiants
pubmed: 34348643
doi: 10.1186/s12865-021-00443-7
pii: 10.1186/s12865-021-00443-7
pmc: PMC8336266
doi:
Substances chimiques
Cell Adhesion Molecules
0
Glycosaminoglycans
0
Tnfaip6 protein, mouse
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
52Subventions
Organisme : NEI NIH HHS
ID : P30 EY007551
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029289
Pays : United States
Organisme : NIH HHS
ID : R01 EY029289
Pays : United States
Organisme : NIH HHS
ID : P30 EY07551
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
J Biol Chem. 2016 Jun 24;291(26):13789-801
pubmed: 27143355
Dev Biol. 1992 Jun;151(2):541-51
pubmed: 1601185
Int J Cell Biol. 2015;2015:745237
pubmed: 26448758
J Cell Sci. 2003 May 15;116(Pt 10):1863-73
pubmed: 12692188
J Biol Chem. 2017 Dec 22;292(51):20845-20858
pubmed: 29122888
Front Neurol. 2014 Apr 09;5:47
pubmed: 24782820
Acta Neuropathol. 2010 Jan;119(1):7-35
pubmed: 20012068
Exp Brain Res. 1998 Aug;121(3):300-10
pubmed: 9746136
J Neurosci. 2013 Jul 31;33(31):12870-86
pubmed: 23904622
J Biol Chem. 2013 Oct 11;288(41):29642-53
pubmed: 24005673
J Biol Chem. 2013 Oct 4;288(40):29090-104
pubmed: 23950179
Neurosci Res. 2018 Jan;126:39-43
pubmed: 29054466
Surg Neurol. 2009 Dec;72 Suppl 2:S50-4
pubmed: 19944826
Curr Opin Neurobiol. 2007 Feb;17(1):120-7
pubmed: 17223033
J Biol Chem. 2016 Sep 16;291(38):19939-52
pubmed: 27435674
Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49
pubmed: 26926297
J Neurosci Res. 2001 Jan 15;63(2):109-15
pubmed: 11169620
Neuron. 1999 Jun;23(2):297-308
pubmed: 10399936
J Biol Chem. 2011 Jul 22;286(29):25675-86
pubmed: 21596748
J Neurosci. 1999 Oct 1;19(19):8182-98
pubmed: 10493720
J Comp Neurol. 1982 Oct 1;210(4):335-56
pubmed: 7142446
J Biol Chem. 1993 Sep 25;268(27):20473-81
pubmed: 8376402
Neural Regen Res. 2016 Nov;11(11):1742-1743
pubmed: 28123405
Exp Neurol. 2008 Feb;209(2):294-301
pubmed: 17617407
Nat Rev Dis Primers. 2016 Nov 17;2:16084
pubmed: 27853132
Cell Commun Signal. 2020 Apr 15;18(1):62
pubmed: 32293472
J Neurosci Res. 2018 Apr;96(4):573-588
pubmed: 29344975
Matrix Biol. 2017 Jul;60-61:38-56
pubmed: 27932299
J Athl Train. 2017 Mar;52(3):309-317
pubmed: 28387556
Exp Neurol. 2015 Dec;274(Pt B):100-14
pubmed: 26277685
Int J Biochem Cell Biol. 2012 Apr;44(4):596-9
pubmed: 22300985
Front Pharmacol. 2019 Sep 27;10:1114
pubmed: 31611796
Neurol Med Chir (Tokyo). 2014;54(11):878-86
pubmed: 25367588
J Neurosci. 1999 Jul 15;19(14):5810-22
pubmed: 10407022
J Biol Chem. 1989 Aug 15;264(23):13840-7
pubmed: 2503506
NeuroRehabilitation. 2007;22(5):341-53
pubmed: 18162698
Biochem Soc Trans. 2007 Aug;35(Pt 4):672-6
pubmed: 17635118
J Neurosci. 2004 Mar 3;24(9):2143-55
pubmed: 14999065
J Biol Chem. 2014 Feb 28;289(9):5619-34
pubmed: 24403066
Nat Med. 2006 Jul;12(7):829-34
pubmed: 16783372
Exp Neurol. 2016 Jan;275 Pt 3:305-315
pubmed: 25828533
J Biol Chem. 2016 Nov 18;291(47):24324-24334
pubmed: 27679489
Cell Tissue Res. 2012 Jul;349(1):169-80
pubmed: 22362507
Prog Brain Res. 2001;132:23-30
pubmed: 11544992
J Neurosci. 2004 May 26;24(21):5016-21
pubmed: 15163694
Exp Neurol. 2015 Jul;269:169-87
pubmed: 25900055
Neuroscientist. 2005 Oct;11(5):400-7
pubmed: 16151042
Nat Rev Neurosci. 2004 Feb;5(2):146-56
pubmed: 14735117
Trends Neurosci. 2009 Dec;32(12):638-47
pubmed: 19782411
J Cell Biol. 1999 May 3;145(3):503-14
pubmed: 10225952
PLoS One. 2015 Jul 29;10(7):e0134371
pubmed: 26222542
J Neurosci. 2006 Apr 19;26(16):4406-14
pubmed: 16624960
Exp Neurol. 1995 Nov;136(1):32-43
pubmed: 7589332
Neuron. 2014 Jan 22;81(2):229-48
pubmed: 24462092
J Neurosci. 2009 Sep 16;29(37):11511-22
pubmed: 19759299
Nat Rev Neurol. 2013 Apr;9(4):222-30
pubmed: 23478462
Nat Rev Neurol. 2014 Mar;10(3):156-66
pubmed: 24514870
J Neuropathol Exp Neurol. 2000 Aug;59(8):641-51
pubmed: 10952055
Dev Neurobiol. 2010 Oct;70(12):826-41
pubmed: 20629049
Neuropathol Appl Neurobiol. 2011 Oct;37(6):570-84
pubmed: 21696410
Brain Res Rev. 2007 Apr;54(1):1-18
pubmed: 17222456
Cold Spring Harb Perspect Biol. 2014 Nov 07;7(2):a020420
pubmed: 25380660
Prog Neurol Surg. 2014;28:234-42
pubmed: 24923407
Nat Neurosci. 2001 May;4(5):465-6
pubmed: 11319553
J Biol Chem. 2013 Jan 4;288(1):205-14
pubmed: 23166324
J Neurosci. 1999 Dec 15;19(24):10778-88
pubmed: 10594061
Eur J Neurosci. 2005 Dec;22(12):3047-58
pubmed: 16367771
Development. 2003 May;130(10):2253-61
pubmed: 12668637
J Biol Chem. 2014 Aug 22;289(34):23465-81
pubmed: 24986866
Mol Neurodegener. 2016 Feb 03;11:14
pubmed: 26842216
J Neurosci. 2008 Jul 9;28(28):7231-43
pubmed: 18614693
J Biol Chem. 2002 Dec 27;277(52):51068-76
pubmed: 12401803
Nature. 2002 Apr 11;416(6881):636-40
pubmed: 11948352
J Neurosci. 1991 Nov;11(11):3398-411
pubmed: 1719160
Biomacromolecules. 2006 Mar;7(3):659-68
pubmed: 16529395
Brain Res Bull. 2011 Mar 10;84(4-5):306-16
pubmed: 20620201
J Neurotrauma. 2011 Nov;28(11):2277-85
pubmed: 21381883
J Infect Dis. 2003 Sep 15;188(6):919-26
pubmed: 12964125
Biol Reprod. 2001 Jul;65(1):301-8
pubmed: 11420253
Brain. 2006 Oct;129(Pt 10):2761-72
pubmed: 16825202
Front Neurol. 2018 Jul 31;9:590
pubmed: 30108544