Genetic insights into biological mechanisms governing human ovarian ageing.

Adult Aging / genetics Alleles Animals Bone and Bones / metabolism Checkpoint Kinase 1 / genetics Checkpoint Kinase 2 / genetics Diabetes Mellitus, Type 2 Diet Europe / ethnology Asia, Eastern / ethnology Female Fertility / genetics Fragile X Mental Retardation Protein / genetics Genetic Predisposition to Disease Genome-Wide Association Study Healthy Aging / genetics Humans Longevity / genetics Menopause / genetics Menopause, Premature / genetics Mice Mice, Inbred C57BL Middle Aged Ovary / metabolism Primary Ovarian Insufficiency / genetics Uterus

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 2021
Historique:
received: 24 08 2020
accepted: 29 06 2021
pubmed: 6 8 2021
medline: 8 10 2021
entrez: 5 8 2021
Statut: ppublish

Résumé

Reproductive longevity is essential for fertility and influences healthy ageing in women

Identifiants

DOI: 10.1038/s41586-021-03779-7 PMID: 34349265 PMC: PMC7611832
pubmed: 34349265
doi: 10.1038/s41586-021-03779-7
pii: 10.1038/s41586-021-03779-7
pmc: PMC7611832
mid: EMS136340
doi:

Substances chimiques

FMR1 protein, human 0
Fragile X Mental Retardation Protein 139135-51-6
Checkpoint Kinase 2 EC 2.7.1.11
Checkpoint Kinase 1 EC 2.7.11.1
Chek1 protein, mouse EC 2.7.11.1
Chek2 protein, mouse EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

393-397

Subventions

Organisme : Medical Research Council
ID : MC_UU_12012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29186
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/2
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P50 CA058223
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12015/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00017/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137686851
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM098605
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 10118
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202802/Z/16/Z
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Organisme : Medical Research Council
ID : MC_PC_17189
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Organisme : Medical Research Council
ID : MC_UU_00014/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
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ID : MC_UU_00006/1
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Organisme : Medical Research Council
ID : MC_UU_12026/2
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ID : U01 HL130114
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13049
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204623/Z/16/Z
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA182913
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_14135
Pays : United Kingdom

Commentaires et corrections

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Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Katherine S Ruth (KS)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Felix R Day (FR)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

Jazib Hussain (J)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Ana Martínez-Marchal (A)

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

Catherine E Aiken (CE)

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

Ajuna Azad (A)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Deborah J Thompson (DJ)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Lucie Knoblochova (L)

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic.
Faculty of Science, Charles University, Prague, Czech Republic.

Hironori Abe (H)

Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Jane L Tarry-Adkins (JL)

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

Javier Martin Gonzalez (JM)

Transgenic Core Facility, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Pierre Fontanillas (P)

23andMe Inc., Sunnyvale, CA, USA.

Annique Claringbould (A)

Structural and Computational Biology Unit, EMBL, Heidelberg, Germany.

Olivier B Bakker (OB)

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.

Patrick Sulem (P)

deCODE genetics/Amgen, Reykjavik, Iceland.

Robin G Walters (RG)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
MRC Population Health Research Unit, University of Oxford, Oxford, UK.

Chikashi Terao (C)

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.
Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

Sandra Turon (S)

Transgenic Animal Unit, Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

Momoko Horikoshi (M)

Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Kuang Lin (K)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.

N Charlotte Onland-Moret (NC)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Aditya Sankar (A)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Emil Peter Thrane Hertz (EPT)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Pascal N Timshel (PN)

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Vallari Shukla (V)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Rehannah Borup (R)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Kristina W Olsen (KW)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Reproductive Medicine, Department of Obstetrics and Gynaecology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Paula Aguilera (P)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Sevilla -Universidad Pablo de Olavide, Seville, Spain.

Mònica Ferrer-Roda (M)

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

Yan Huang (Y)

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

Stasa Stankovic (S)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

Paul R H J Timmers (PRHJ)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Thomas U Ahearn (TU)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Behrooz Z Alizadeh (BZ)

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Elnaz Naderi (E)

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Irene L Andrulis (IL)

Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Alice M Arnold (AM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Kristan J Aronson (KJ)

Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.

Annelie Augustinsson (A)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.

Stefania Bandinelli (S)

Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.

Caterina M Barbieri (CM)

Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Robin N Beaumont (RN)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Heiko Becher (H)

Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Matthias W Beckmann (MW)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Stefania Benonisdottir (S)

deCODE genetics/Amgen, Reykjavik, Iceland.

Sven Bergmann (S)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Murielle Bochud (M)

University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.

Eric Boerwinkle (E)

Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Stig E Bojesen (SE)

Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Manjeet K Bolla (MK)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Dorret I Boomsma (DI)

Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.

Nicholas Bowker (N)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

Jennifer A Brody (JA)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.

Linda Broer (L)

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Julie E Buring (JE)

Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Archie Campbell (A)

Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Harry Campbell (H)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

Jose E Castelao (JE)

Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.

Eulalia Catamo (E)

Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Georgia Chenevix-Trench (G)

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Marina Ciullo (M)

Institute of Genetics and Biophysics - CNR, Naples, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.

Tanguy Corre (T)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.

Fergus J Couch (FJ)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Angela Cox (A)

Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Laura Crisponi (L)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.

Simon S Cross (SS)

Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.

Francesco Cucca (F)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
University of Sassari, Department of Biomedical Sciences, Sassari, Italy.

Kamila Czene (K)

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.

George Davey Smith (GD)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.

Eco J C N de Geus (EJCN)

Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.

Renée de Mutsert (R)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Immaculata De Vivo (I)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Ellen W Demerath (EW)

Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis, MN, USA.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Alison M Dunning (AM)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Miriam Dwek (M)

School of Life Sciences, University of Westminster, London, UK.

Mikael Eriksson (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Tõnu Esko (T)

Population and Medical Genetics, Broad Institute, Cambridge, MA, USA.
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Peter A Fasching (PA)

Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA.

Jessica D Faul (JD)

Survey Research Center, Institute for Social Research, Ann Arbor, MI, USA.

Luigi Ferrucci (L)

Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.

Nora Franceschini (N)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

Timothy M Frayling (TM)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Manuela Gago-Dominguez (M)

Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

Massimo Mezzavilla (M)

Department of Medical Sciences, University of Trieste, Trieste, Italy.

Montserrat García-Closas (M)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Harald Grallert (H)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Daniel F Gudbjartsson (DF)

deCODE genetics/Amgen, Reykjavik, Iceland.

Vilmundur Gudnason (V)

Icelandic Heart Association, Kopavogur, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Pascal Guénel (P)

Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Niclas Håkansson (N)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Per Hall (P)

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Chunyan He (C)

Division of Medical Oncology, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
The Cancer Prevention and Control Research Program, University of Kentucky Markey Cancer Center, Lexington, KY, USA.

Wei He (W)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Gerardo Heiss (G)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

Miya K Høffding (MK)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Jouke J Hottenga (JJ)

Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.

Frank Hu (F)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

David Hunter (D)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Mohammad A Ikram (MA)

Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Rebecca D Jackson (RD)

Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

Micaella D R Joaquim (MDR)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Esther M John (EM)

Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Peter K Joshi (PK)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

David Karasik (D)

Harvard Medical School, Boston, MA, USA.
Hebrew SeniorLife Institute for Aging Research, Boston, MA, USA.

Sharon L R Kardia (SLR)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Christiana Kartsonaki (C)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
MRC Population Health Research Unit, University of Oxford, Oxford, UK.

Robert Karlsson (R)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Cari M Kitahara (CM)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Ivana Kolcic (I)

Faculty of Medicine, University of Split, Split, Croatia.

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Peter Kraft (P)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Allison W Kurian (AW)

Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Zoltan Kutalik (Z)

Swiss Institute of Bioinformatics, Lausanne, Switzerland.
University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.

Martina La Bianca (M)

Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.

Genevieve LaChance (G)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Claudia Langenberg (C)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

Lenore J Launer (LJ)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.

Joop S E Laven (JSE)

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Deborah A Lawlor (DA)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.

Loic Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Jingmei Li (J)

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.

Annika Lindblom (A)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.

Sara Lindstrom (S)

Department of Epidemiology, University of Washington, Seattle, WA, USA.

Tricia Lindstrom (T)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Martha Linet (M)

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

YongMei Liu (Y)

Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Wake Forest, NC, USA.

Simin Liu (S)

Department of Epidemiology, Brown University, Providence, RI, USA.
Department of Medicine, Brown University, Providence, RI, USA.

Jian'an Luan (J)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

Reedik Mägi (R)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Patrik K E Magnusson (PKE)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Massimo Mangino (M)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.

Arto Mannermaa (A)

Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.

Brumat Marco (B)

Department of Medical Sciences, University of Trieste, Trieste, Italy.

Jonathan Marten (J)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.

Hamdi Mbarek (H)

Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.

Barbara McKnight (B)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Sarah E Medland (SE)

QIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.

Christa Meisinger (C)

Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany.

Thomas Meitinger (T)

Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Cristina Menni (C)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Andres Metspalu (A)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Lili Milani (L)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Grant W Montgomery (GW)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Dennis O Mook-Kanamori (DO)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.

Antonella Mulas (A)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.

Anna M Mulligan (AM)

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

Alison Murray (A)

The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.

Mike A Nalls (MA)

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

Anne Newman (A)

Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Raymond Noordam (R)

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

Teresa Nutile (T)

Institute of Genetics and Biophysics - CNR, Naples, Italy.

Dale R Nyholt (DR)

Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

Andrew F Olshan (AF)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Håkan Olsson (H)

Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.

Jodie N Painter (JN)

QIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.

Alpa V Patel (AV)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Nancy L Pedersen (NL)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Natalia Perjakova (N)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

Annette Peters (A)

Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Ulrike Peters (U)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Paul D P Pharoah (PDP)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Ozren Polasek (O)

Faculty of Medicine, University of Split, Split, Croatia.
Gen-Info Ltd, Zagreb, Croatia.

Eleonora Porcu (E)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.

Iffat Rahman (I)

Quantify Research, Stockholm, Sweden.

Gad Rennert (G)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.

Hedy S Rennert (HS)

Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.

Paul M Ridker (PM)

Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Susan M Ring (SM)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.

Antonietta Robino (A)

Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.

Lynda M Rose (LM)

Brigham and Women's Hospital, Boston, MA, USA.

Frits R Rosendaal (FR)

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Jacques Rossouw (J)

Women's Health Initiative Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.

Igor Rudan (I)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

Rico Rueedi (R)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Daniela Ruggiero (D)

Institute of Genetics and Biophysics - CNR, Naples, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.

Cinzia F Sala (CF)

Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Emmanouil Saloustros (E)

Department of Oncology, University Hospital of Larissa, Larissa, Greece.

Dale P Sandler (DP)

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Serena Sanna (S)

Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.

Elinor J Sawyer (EJ)

School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, UK.

Chloé Sarnowski (C)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

David Schlessinger (D)

National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.

Marjanka K Schmidt (MK)

Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Minouk J Schoemaker (MJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Katharina E Schraut (KE)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.

Christopher Scott (C)

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Saleh Shekari (S)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Amruta Shrikhande (A)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Albert V Smith (AV)

Icelandic Heart Association, Kopavogur, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Blair H Smith (BH)

Division of Population and Health Genomics, University of Dundee, Dundee, UK.

Jennifer A Smith (JA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Rossella Sorice (R)

Institute of Genetics and Biophysics - CNR, Naples, Italy.

Melissa C Southey (MC)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.

Tim D Spector (TD)

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

John J Spinelli (JJ)

Population Oncology, BC Cancer, Vancouver, British Columbia, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Meir Stampfer (M)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Doris Stöckl (D)

Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.

Joyce B J van Meurs (JBJ)

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Konstantin Strauch (K)

Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.

Unnur Styrkarsdottir (U)

deCODE genetics/Amgen, Reykjavik, Iceland.

Anthony J Swerdlow (AJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.

Toshiko Tanaka (T)

Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.

Lauren R Teras (LR)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Unnur Þorsteinsdottir (U)

deCODE genetics/Amgen, Reykjavik, Iceland.
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

Nicholas J Timpson (NJ)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.

Daniela Toniolo (D)

Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Michela Traglia (M)

Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Melissa A Troester (MA)

Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Thérèse Truong (T)

Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.

Jessica Tyrrell (J)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

André G Uitterlinden (AG)

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Sheila Ulivi (S)

Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.

Celine M Vachon (CM)

Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Veronique Vitart (V)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Uwe Völker (U)

Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Peter Vollenweider (P)

Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Henry Völzke (H)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Qin Wang (Q)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

Clarice R Weinberg (CR)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

David R Weir (DR)

Survey Research Center, Institute for Social Research, Ann Arbor, MI, USA.

Amber N Wilcox (AN)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Ko Willems van Dijk (KW)

Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

Gonneke Willemsen (G)

Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam, The Netherlands.

James F Wilson (JF)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Bruce H R Wolffenbuttel (BHR)

Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Andrew R Wood (AR)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Wei Zhao (W)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Marek Zygmunt (M)

Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.

Zhengming Chen (Z)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
MRC Population Health Research Unit, University of Oxford, Oxford, UK.

Liming Li (L)

School of Public Health, Peking University Health Science Center, Beijing, P.R. China.
Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, P.R. China.

Lude Franke (L)

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Stephen Burgess (S)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Patrick Deelen (P)

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.

Tune H Pers (TH)

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Marie Louise Grøndahl (ML)

Reproductive Medicine, Department of Obstetrics and Gynaecology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Claus Yding Andersen (CY)

Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Anna Pujol (A)

Transgenic Animal Unit, Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

Andres J Lopez-Contreras (AJ)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Sevilla -Universidad Pablo de Olavide, Seville, Spain.

Jeremy A Daniel (JA)

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Kari Stefansson (K)

deCODE genetics/Amgen, Reykjavik, Iceland.
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Yvonne T van der Schouw (YT)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Kathryn L Lunetta (KL)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA.

Daniel I Chasman (DI)

Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Jenny A Visser (JA)

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Susan E Ozanne (SE)

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Satoshi H Namekawa (SH)

Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Petr Solc (P)

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic.

Joanne M Murabito (JM)

NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA, USA.

Ken K Ong (KK)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.

Eva R Hoffmann (ER)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. eva@sund.ku.dk.
ORCID: 0000-0002-2588-0652

Anna Murray (A)

Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. a.murray@exeter.ac.uk.
ORCID: 0000-0002-2351-2522

Ignasi Roig (I)

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. ignasi.roig@uab.cat.
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. ignasi.roig@uab.cat.
ORCID: 0000-0003-0313-3581

John R B Perry (JRB)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. john.perry@mrc-epid.cam.ac.uk.
ORCID: 0000-0001-6483-3771

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic insights into biological mechanisms...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Genetic insights into biological mechanisms...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Genetic insights into biological mechanisms...
questionsmedicales.fr › Eucaryotes › Animaux › Genetic insights into biological mechanisms...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Genetic insights into biological mechanisms...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Checkpoint kinase 1 › Genetic insights into biological mechanisms...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Checkpoint kinase 2 › Genetic insights into biological mechanisms...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Genetic insights into biological mechanisms...
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questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Fécondité › Genetic insights into biological mechanisms...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéine du syndrome X fragile › Genetic insights into biological mechanisms...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic insights into biological mechanisms...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetic insights into biological mechanisms...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic insights into biological mechanisms...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Genetic insights into biological mechanisms...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Genetic insights into biological mechanisms...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Ménopause précoce › Genetic insights into biological mechanisms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Genetic insights into biological mechanisms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Genetic insights into biological mechanisms...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic insights into biological mechanisms...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Ovaire › Genetic insights into biological mechanisms...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Insuffisance ovarienne primitive › Genetic insights into biological mechanisms...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de la femme › Utérus › Genetic insights into biological mechanisms...