Low level of plasminogen increases risk for mortality in COVID-19 patients.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
05 08 2021
05 08 2021
Historique:
received:
08
07
2021
accepted:
27
07
2021
revised:
26
07
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
12
8
2021
Statut:
epublish
Résumé
The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still not fully understood. In fact, a very high number of patients with COVID-19 die because of thromboembolic causes. A role of plasminogen, as precursor of fibrinolysis, has been hypothesized. In this study, we aimed to investigate the association between plasminogen levels and COVID-19-related outcomes in a population of 55 infected Caucasian patients (mean age: 69.8 ± 14.3, 41.8% female). Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR, and APTT), and markers of organ dysfunctions (high fasting blood glucose and decrease in the glomerular filtration rate). A multidimensional analysis model, including the correlation of the expression of coagulation with inflammatory parameters, indicated that plasminogen tended to cluster together with IL-6, hence suggesting a common pathway of activation during disease's complication. Moreover, low levels of plasminogen strongly correlated with mortality in COVID-19 patients even after multiple adjustments for presence of confounding. These data suggest that plasminogen may play a pivotal role in controlling the complex mechanisms beyond the COVID-19 complications, and may be useful both as biomarker for prognosis and for therapeutic target against this extremely aggressive infection.
Identifiants
pubmed: 34354045
doi: 10.1038/s41419-021-04070-3
pii: 10.1038/s41419-021-04070-3
pmc: PMC8340078
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Plasminogen
9001-91-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
773Informations de copyright
© 2021. The Author(s).
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