Prevalence of Peripheral Polyneuropathy Before and After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.
Bariatric surgery
Obesity
Peripheral polyneuropathy
Journal
Obesity surgery
ISSN: 1708-0428
Titre abrégé: Obes Surg
Pays: United States
ID NLM: 9106714
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
31
03
2021
accepted:
09
07
2021
revised:
28
06
2021
pubmed:
7
8
2021
medline:
26
10
2021
entrez:
6
8
2021
Statut:
ppublish
Résumé
Peripheral polyneuropathy (PPN) can occur in diabetes mellitus (DM), obesity, and after bariatric surgery (BS). We decided to evaluate PPN prevalence before (PreBS-PPN) and after BS (PostBS-PPN) and to look for variables that may be independently associated with both. In this cross-sectional study, we evaluated 1467 participants with obesity and without DM before and 10.4 ± 6.8 months after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). The Michigan Neuropathy Screening Instrument and the International Physical Activity Questionnaire were used to define the presence of PPN and the Metabolic Equivalent Task (MET) spent per week, respectively. Using Poisson regression models with a robust estimator, the prevalence of PreBS-PPN and PostBS-PPN was analyzed as dependent variables. Prevalence of PostBS-PPN (10.5%) was lower than PreBS-PPN (20.4%, p < 0.001), with a prevalence of 12.7% post-RYGB and 8.4% post-SG (p = 0.072). In the univariate analysis, PreBS-PPN was associated with post-menopausal status (PMS), older age, and taller height. In twelve regression models, we found an independent association of PreBS-PPN with older age, PMS, and taller height. PostBS-PPN prevalence was associated with a higher fasting glycemia and stature, and a lower MET on univariate analysis, and with higher fasting glycemia, stature and RYGB in four multivariate regression models. PPN occurs frequently in subjects with obesity without DM and is lower after BS. SG is not likely to be harmful in the development of neuropathy. Studies of PPN incidence and persistence after BS should clarify these factors.
Identifiants
pubmed: 34355339
doi: 10.1007/s11695-021-05606-4
pii: 10.1007/s11695-021-05606-4
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4427-4435Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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