Calcium oxalate urolithiasis in juvenile dogs.
bulldog
hyperuricosuria
paediatric
predispositions
urinary stones
Journal
The Veterinary record
ISSN: 2042-7670
Titre abrégé: Vet Rec
Pays: England
ID NLM: 0031164
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
10
11
2020
received:
29
01
2020
accepted:
26
01
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
26
10
2021
Statut:
ppublish
Résumé
The features of juvenile-onset calcium oxalate urolithiasis in dogs have not been previously reported. Calcium oxalate urolith submissions to the Minnesota Urolith Center between 2012 and 2016 were analyzed to identify those originating from juvenile (≤2 years, n = 510) or mature (7-9 years, n = 39,093) dogs. Breed, sex, urolith salt type and urolith location were compared between groups. Breeds represented in both groups were also compared with respect to sex, urolith salt type and urolith location. French (odds ratios [OR] = 14.7, p < 0.001) and English (OR = 14.3, p < 0.001) Bulldogs were overrepresented in juvenile submissions. All juvenile French and English Bulldogs were male. Across all breeds, juvenile dogs were more likely to be male (89%, p < 0.001) than mature dogs (79%). Juvenile dogs were also more likely to form dihydrate stones compared to mature dogs (33% versus 14%, respectively; p < 0.001). Breed differences were discovered in sex, urolith salt type and stone location. French and English Bulldogs comprise a greater proportion of juvenile calcium oxalate urolith submissions than expected based on their rarity in mature submissions. Inherited risk factors, particularly X chromosome variants, should be investigated due to the strong breed and sex predispositions identified.
Sections du résumé
BACKGROUND
BACKGROUND
The features of juvenile-onset calcium oxalate urolithiasis in dogs have not been previously reported.
METHODS
METHODS
Calcium oxalate urolith submissions to the Minnesota Urolith Center between 2012 and 2016 were analyzed to identify those originating from juvenile (≤2 years, n = 510) or mature (7-9 years, n = 39,093) dogs. Breed, sex, urolith salt type and urolith location were compared between groups. Breeds represented in both groups were also compared with respect to sex, urolith salt type and urolith location.
RESULTS
RESULTS
French (odds ratios [OR] = 14.7, p < 0.001) and English (OR = 14.3, p < 0.001) Bulldogs were overrepresented in juvenile submissions. All juvenile French and English Bulldogs were male. Across all breeds, juvenile dogs were more likely to be male (89%, p < 0.001) than mature dogs (79%). Juvenile dogs were also more likely to form dihydrate stones compared to mature dogs (33% versus 14%, respectively; p < 0.001). Breed differences were discovered in sex, urolith salt type and stone location.
CONCLUSIONS
CONCLUSIONS
French and English Bulldogs comprise a greater proportion of juvenile calcium oxalate urolith submissions than expected based on their rarity in mature submissions. Inherited risk factors, particularly X chromosome variants, should be investigated due to the strong breed and sex predispositions identified.
Identifiants
pubmed: 34357620
doi: 10.1002/vetr.141
pmc: PMC9159368
mid: NIHMS1808542
doi:
Substances chimiques
Calcium Oxalate
2612HC57YE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e141Subventions
Organisme : NIH HHS
ID : K01 OD019912
Pays : United States
Organisme : National Institute of Health ORIP K01 Mentored Research Scientist Development Award
ID : K01-OD019912
Informations de copyright
© 2021 British Veterinary Association.
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