Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease.
Anxiety
Norepinephrine
Parkinson disease
Pink1
Rat
Ultrasonic vocalization
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
24 09 2021
24 09 2021
Historique:
received:
01
06
2021
revised:
23
07
2021
accepted:
30
07
2021
pubmed:
7
8
2021
medline:
15
2
2022
entrez:
6
8
2021
Statut:
ppublish
Résumé
Vocal communication impairment and anxiety are co-occurring and interacting signs of Parkinson Disease (PD) that are common, poorly understood, and under-treated. Both vocal communication and anxiety are influenced by the noradrenergic system. In light of this shared neural substrate and considering that noradrenergic dysfunction is a defining characteristic of PD, tandem investigation of vocal impairment and anxiety in PD relative to noradrenergic mechanisms is likely to yield insights into the underlying disease-specific causes of these impairments. In order to address this gap in knowledge, we assessed vocal impairment and anxiety behavior relative to brainstem noradrenergic markers in a genetic rat model of early-onset PD (Pink1-/-) and wild type controls (WT). We hypothesized that 1) brainstem noradrenergic markers would be disrupted in Pink1-/-, and 2) brainstem noradrenergic markers would be associated with vocal acoustic changes and anxiety level. Rats underwent testing of ultrasonic vocalization and anxiety (elevated plus maze) at 4, 8, and 12 months of age. At 12 months, brainstem norepinephrine markers were quantified with immunohistochemistry. Results demonstrated that vocal impairment and anxiety were increased in Pink1-/- rats, and increased anxiety was associated with greater vocal deficit in this model of PD. Further, brainstem noradrenergic markers including TH and α1 adrenoreceptor immunoreactivity in the locus coeruleus, and β1 adrenoreceptor immunoreactivity in vagal nuclei differed by genotype, and were associated with vocalization and anxiety behavior. These findings demonstrate statistically significant relationships among vocal impairment, anxiety, and brainstem norepinephrine in the Pink1-/- rat model of PD.
Identifiants
pubmed: 34358571
pii: S0166-4328(21)00402-2
doi: 10.1016/j.bbr.2021.113514
pmc: PMC8393386
mid: NIHMS1731455
pii:
doi:
Substances chimiques
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113514Subventions
Organisme : NIDCD NIH HHS
ID : T32 DC009401
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014358
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117469
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC018584
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC016135
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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