In silico drug repurposing in COVID-19: A network-based analysis.
Anti-Inflammatory Agents
/ pharmacology
COVID-19
/ prevention & control
Central Nervous System Agents
/ pharmacology
Computer Simulation
Drug Repositioning
/ methods
Enzyme Inhibitors
/ pharmacology
Gene Expression Profiling
/ methods
Humans
Immunologic Factors
/ pharmacology
Treatment Outcome
Voltage-Gated Sodium Channel Blockers
/ pharmacology
COVID-19 Drug Treatment
COVID-19
Corticosteroid
Drug repurposing
Heparin
Inflammatory bowel disease
Septic shock
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
07
05
2021
revised:
15
07
2021
accepted:
20
07
2021
pubmed:
7
8
2021
medline:
28
9
2021
entrez:
6
8
2021
Statut:
ppublish
Résumé
The SARS-CoV-2 pandemic is a worldwide public health emergency. Despite the beginning of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 patients remains a priority. Drug repurposing represents a faster and cheaper method than de novo drug discovery. In this study, we examined three different network-based approaches to identify potentially repurposable drugs to treat COVID-19. We analyzed transcriptomic data from whole blood cells of patients with COVID-19 and 21 other related conditions, as compared with those of healthy subjects. In addition to conventionally used drugs (e.g., anticoagulants, antihistaminics, anti-TNFα antibodies, corticosteroids), unconventional candidate compounds, such as SCN5A inhibitors and drugs active in the central nervous system, were identified. Clinical judgment and validation through clinical trials are always mandatory before use of the identified drugs in a clinical setting.
Identifiants
pubmed: 34358753
pii: S0753-3322(21)00736-8
doi: 10.1016/j.biopha.2021.111954
pmc: PMC8316014
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Central Nervous System Agents
0
Enzyme Inhibitors
0
Immunologic Factors
0
Voltage-Gated Sodium Channel Blockers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111954Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
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