Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation.

Adaptor Proteins, Signal Transducing / deficiency Animals Cells, Cultured Cytokines / biosynthesis Interleukin-33 / metabolism Mast Cells / metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout
IL-33 Mast cells NF-κB ST2 Signal-transducing adaptor molecule-2

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
01 10 2021
Historique:
received: 16 07 2021
revised: 21 07 2021
accepted: 29 07 2021
pubmed: 7 8 2021
medline: 18 11 2021
entrez: 6 8 2021
Statut: ppublish

Résumé

Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of FcεRI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet. In the present study, we mainly investigated functional roles of STAP-2 in IL-33-induced mast cell activation. In STAP-2-deficient, but not STAP-1-deficient, mast cells, IL-33-induced IL-6 and TNF-α production was significantly decreased compared with that of wild-type mast cells. In addition, STAP-2-deficiency greatly reduced TLR4-mediated mast cell activation and cytokine production. For the mechanisms, STAP-2 directly binds to IKKα after IL-33 stimulation, leading to elevated NF-κB activity. In conclusion, STAP-2, but not STAP-1, participates in IL-33-induced mast cells activation.

Identifiants

DOI: 10.1016/j.bbrc.2021.07.098 PMID: 34358967
pubmed: 34358967
pii: S0006-291X(21)01136-0
doi: 10.1016/j.bbrc.2021.07.098
pii:
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Cytokines 0
Il33 protein, mouse 0
Interleukin-33 0
STAP2 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

80-85

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Jun-Ichi Kashiwakura (JI)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan. Electronic address: junkashi@pharm.hokudai.ac.jp.

Nao Koizumi (N)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Kodai Saitoh (K)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Kota Kagohashi (K)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Yuto Sasaki (Y)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Fuki Kobayashi (F)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Shoya Kawahara (S)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Yukie Yamauchi (Y)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Yuichi Kitai (Y)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Ryuta Muromoto (R)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan.

Kenji Oritani (K)

Department of Hematology, International University of Health and Welfare, 4-3 Kouzunomori, Narita, Chiba, 286-8686, Japan.

Tadashi Matsuda (T)

Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-Ku, Sapporo, Hokkaido, 060-0812, Japan. Electronic address: tmatsuda@pharm.hokudai.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Eucaryotes › Animaux › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Cellules › Cellules cultivées › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-33 › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Mastocytes › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Signal-transducing adaptor protein-2 has a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Signal-transducing adaptor protein-2 has a...