Kenji Oritani

Affiliations

Department of Hematology, Graduate School of Medical Sciences, International University of Health and Welfare Hospital, Narita, Japan.

Publications (36)

Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function.

Leukemia

Avec: Yasuhiro Nagate , Sachiko Ezoe , Jiro Fujita , Daisuke Okuzaki , Daisuke Motooka , Tomohiko Ishibashi , Michiko Ichii , Akira Tanimura , Masako Kurashige , Eiichi Morii , Takuya Fukushima , Youko Suehiro , Takafumi Yokota , Hirohiko Shibayama , Kenji Oritani , Yuzuru Kanakura

Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.

Biochemical and biophysical research communications

Avec: Hideaki Saito , Michiko Ichii , Jun Toda , Yuichi Kitai , Ryuta Muromoto , Jun-Ichi Kashiwakura , Kodai Saitoh , Akira Tanimura , Takafumi Yokota , Hirohiko Shibayama , Tadashi Matsuda , Kenji Oritani , Yuzuru Kanakura , Naoki Hosen

STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses.

Biological & pharmaceutical bulletin

Avec: Tadashi Matsuda , Kenji Oritani

STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Kodai Saitoh , Jun-Ichi Kashiwakura , Kota Kagohashi , Yuto Sasaki , Shoya Kawahara , Yuichi Sekine , Yuichi Kitai , Ryuta Muromoto , Michiko Ichii , Hiroko Nakatsukasa , Akihiko Yoshimura , Kenji Oritani , Tadashi Matsuda

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.

Haematologica

Avec: Michiko Ichii , Kenji Oritani , Jun Toda , Hideaki Saito , Henyun Shi , Hirohiko Shibayama , Daisuke Motooka , Yuichi Kitai , Ryuta Muromoto , Jun-Ichi Kashiwakura , Kodai Saitoh , Daisuke Okuzaki , Tadashi Matsuda , Yuzuru Kanakura

Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.

PloS one

Avec: Jun-Ichi Kashiwakura , Kodai Saitoh , Takeru Ihara , Yuto Sasaki , Kota Kagohashi , Shiyo Enohara , Yuka Morioka , Hiroshi Watarai , Ryuta Muromoto , Yuichi Kitai , Kazuya Iwabuchi , Kenji Oritani , Tadashi Matsuda

Current understanding of the role of tyrosine kinase 2 signaling in immune responses.

World journal of biological chemistry

Avec: Ryuta Muromoto , Kenji Oritani , Tadashi Matsuda

A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling.

The Journal of biological chemistry

Avec: Taiga Maemoto , Yuichi Kitai , Runa Takahashi , Haruka Shoji , Shunsuke Yamada , Shiho Takei , Daiki Ito , Ryuta Muromoto , Jun-Ichi Kashiwakura , Haruka Handa , Ari Hashimoto , Shigeru Hashimoto , Toyoyuki Ose , Kenji Oritani , Tadashi Matsuda

Positive interactions between STAP-1 and BCR-ABL influence chronic myeloid leukemia cell proliferation and survival.

Biochemical and biophysical research communications

Avec: Marie Ishiura , Yuichi Kitai , Jun-Ichi Kashiwakura , Ryuta Muromoto , Jun Toda , Michiko Ichii , Kenji Oritani , Tadashi Matsuda

A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820.

International immunology

Avec: Yuichi Sekine , Kazuna Kikkawa , Bruce A Witthuhn , Jun-Ichi Kashiwakura , Ryuta Muromoto , Yuichi Kitai , Masahiro Fujimuro , Kenji Oritani , Tadashi Matsuda

Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Kota Kagohashi , Yuto Sasaki , Kiyotaka Ozawa , Takuya Tsuchiya , Shoya Kawahara , Kodai Saitoh , Michiko Ichii , Jun Toda , Yasuyo Harada , Masato Kubo , Yuichi Kitai , Ryuta Muromoto , Kenji Oritani , Jun-Ichi Kashiwakura , Tadashi Matsuda

Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance.

Cells

Avec: Shigeru Hashimoto , Ari Hashimoto , Ryuta Muromoto , Yuichi Kitai , Kenji Oritani , Tadashi Matsuda

The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders.

Biomedicines

Avec: Jun-Ichi Kashiwakura , Kenji Oritani , Tadashi Matsuda

STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.

FEBS letters

Avec: Jun-Ichi Kashiwakura , Shoya Kawahara , Iori Inagaki , Kyosuke Inui , Kodai Saitoh , Kota Kagohashi , Yuto Sasaki , Fuki Kobayashi , Yuichi Kitai , Ryuta Muromoto , Kenji Oritani , Tadashi Matsuda

Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.

Oncogene

Avec: Jun Toda , Michiko Ichii , Kenji Oritani , Hirohiko Shibayama , Akira Tanimura , Hideaki Saito , Takafumi Yokota , Daisuke Motooka , Daisuke Okuzaki , Yuichi Kitai , Ryuta Muromoto , Jun-Ichi Kashiwakura , Tadashi Matsuda , Naoki Hosen , Yuzuru Kanakura

Hydrodecyanation of Secondary Alkyl Nitriles and Malononitriles to Alkanes using DiMeImd-BH

The Journal of organic chemistry

Avec: Takuji Kawamoto , Kyohei Oritani , Atsushi Kawabata , Tsubasa Morioka , Hiroshi Matsubara , Akio Kamimura

Pre- and post-serial metagenomic analysis of gut microbiota as a prognostic factor in patients undergoing haematopoietic stem cell transplantation.

British journal of haematology

Avec: Shinsuke Kusakabe , Kentaro Fukushima , Tetsuo Maeda , Daisuke Motooka , Shota Nakamura , Jiro Fujita , Takafumi Yokota , Hirohiko Shibayama , Kenji Oritani , Yuzuru Kanakura

Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IκB-ζ expression.

Biochemical and biophysical research communications

Avec: Yui Ohgakiuchi , Yuka Saino , Ryuta Muromoto , Yuki Komori , Ami Sato , Koki Hirashima , Yuichi Kitai , Jun-Ichi Kashiwakura , Kenji Oritani , Tadashi Matsuda

IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17-Regulated mRNA Stabilization.

ImmunoHorizons

Avec: Ryuta Muromoto , Keisuke Tawa , Yui Ohgakiuchi , Ami Sato , Yuka Saino , Koki Hirashima , Hiroya Minoguchi , Yuichi Kitai , Jun-Ichi Kashiwakura , Kazuya Shimoda , Kenji Oritani , Tadashi Matsuda

CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation.

International immunology

Avec: Yuichi Kitai , Marie Ishiura , Kodai Saitoh , Naoki Matsumoto , Kimiya Owashi , Shunsuke Yamada , Ryuta Muromoto , Jun-Ichi Kashiwakura , Kenji Oritani , Tadashi Matsuda

Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases.

Biological & pharmaceutical bulletin

Avec: Ryuta Muromoto , Kazuya Shimoda , Kenji Oritani , Tadashi Matsuda

Impaired B cell terminal differentiation in B cell-specific knockout mice of cell death-defying factor anamorsin.

Biochemical and biophysical research communications

Avec: Yuri Hamanaka , Akira Tanimura , Takafumi Yokota , Sachiko Ezoe , Michiko Ichii , Yasuhiro Nagate , Kenji Oritani , Yuzuru Kanakura , Naoki Hosen , Hirohiko Shibayama

Correction: Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.

PloS one

High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder.

International journal of hematology

Avec: Hideaki Saito , Hiroaki Miyoshi , Hirohiko Shibayama , Jun Toda , Shinsuke Kusakabe , Michiko Ichii , Jiro Fujita , Kentaro Fukushima , Tetsuo Maeda , Masao Mizuki , Kenji Oritani , Masao Seto , Takafumi Yokota , Yuzuru Kanakura , Naoki Hosen , Koichi Ohshima

STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions.

International immunology

Avec: Jun-Ichi Kashiwakura , Shinsuke Yamashita , Mari Yoshihara , Kyosuke Inui , Kodai Saitoh , Yuichi Sekine , Ryuta Muromoto , Yuichi Kitai , Kenji Oritani , Tadashi Matsuda

Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.

Stem cell reports

Avec: Tomoaki Ueda , Takafumi Yokota , Daisuke Okuzaki , Yoshihiro Uno , Tomoji Mashimo , Yoshiaki Kubota , Takao Sudo , Tomohiko Ishibashi , Yasuhiro Shingai , Yukiko Doi , Takayuki Ozawa , Ritsuko Nakai , Akira Tanimura , Michiko Ichii , Sachiko Ezoe , Hirohiko Shibayama , Kenji Oritani , Yuzuru Kanakura

Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.

Nature communications

Avec: Shinya Rai , Hirokazu Tanaka , Mai Suzuki , J Luis Espinoza , Takahiro Kumode , Akira Tanimura , Takafumi Yokota , Kenji Oritani , Toshio Watanabe , Yuzuru Kanakura , Itaru Matsumura

Limbic encephalitis with antibodies to N-methyl-D-aspartate (NMDA)-type glutamate receptor after allogeneic transplantation.

International journal of hematology

Avec: Jun Toda , Tetsuo Maeda , Keigo Akuta , Shinsuke Kusakabe , Tomoaki Ueda , Jiro Fujita , Hirohiko Shibayama , Kenji Oritani , Yukitoshi Takahashi , Yuzuru Kanakura

The mechanism of Tyk2 deficiency-induced immunosuppression in mice involves robust IL-10 production in macrophages.

Cytokine

Avec: Koki Hirashima , Ryuta Muromoto , Hiroya Minoguchi , Tomohiro Matsumoto , Yuichi Kitai , Jun-Ichi Kashiwakura , Kazuya Shimoda , Kenji Oritani , Tadashi Matsuda

Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation.

Biochemical and biophysical research communications

Avec: Jun-Ichi Kashiwakura , Nao Koizumi , Kodai Saitoh , Kota Kagohashi , Yuto Sasaki , Fuki Kobayashi , Shoya Kawahara , Yukie Yamauchi , Yuichi Kitai , Ryuta Muromoto , Kenji Oritani , Tadashi Matsuda

Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases.

Experimental hematology

Avec: Michiko Ichii , Kenji Oritani , Jun Toda , Naoki Hosen , Tadashi Matsuda , Yuzuru Kanakura

Possible Therapeutic Applications of Targeting STAP Proteins in Cancer.

Biological & pharmaceutical bulletin

Avec: Tadashi Matsuda , Kenji Oritani

Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis.

Biological & pharmaceutical bulletin

Avec: Yuto Sasaki , Kodai Saitoh , Kota Kagohashi , Yuichi Kitai , Ryuta Muromoto , Kenji Oritani , Jun-Ichi Kashiwakura , Tadashi Matsuda

Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications.

Exploration of targeted anti-tumor therapy

Avec: Taiga Maemoto , Yuto Sasaki , Fumiya Okuyama , Yuichi Kitai , Kenji Oritani , Tadashi Matsuda

STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Yuto Sasaki , Kodai Saitoh , Kota Kagohashi , Toyoyuki Ose , Shoya Kawahara , Yuichi Kitai , Ryuta Muromoto , Yuichi Sekine , Michiko Ichii , Akihiko Yoshimura , Kenji Oritani , Jun-Ichi Kashiwakura , Tadashi Matsuda

STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.

Scientific reports

Avec: Yuichi Sekine , Kazuna Kikkawa , Sachie Honda , Yuto Sasaki , Shoya Kawahara , Akihiro Mizushima , Sumihito Togi , Masahiro Fujimuro , Kenji Oritani , Tadashi Matsuda

Réseau de co-auteurs

Tadashi Matsuda 28 collaborations

Ryuta Muromoto 22 collaborations

Yuichi Kitai 21 collaborations

Jun-Ichi Kashiwakura 20 collaborations

Michiko Ichii 12 collaborations

Kodai Saitoh 12 collaborations

Yuzuru Kanakura 11 collaborations

Yuto Sasaki 10 collaborations

Hirohiko Shibayama 9 collaborations

Takafumi Yokota 8 collaborations

Jun Toda 8 collaborations

Kota Kagohashi 8 collaborations

Akira Tanimura 6 collaborations

Shoya Kawahara 6 collaborations

Naoki Hosen 5 collaborations

Yuichi Sekine 5 collaborations

Jiro Fujita 4 collaborations

Daisuke Okuzaki 4 collaborations

Daisuke Motooka 4 collaborations

Hideaki Saito 4 collaborations

Sachiko Ezoe 3 collaborations

Shinsuke Kusakabe 3 collaborations

Tetsuo Maeda 3 collaborations

Koki Hirashima 3 collaborations

Kazuya Shimoda 3 collaborations

Yasuhiro Nagate 2 collaborations

Tomohiko Ishibashi 2 collaborations

Akihiko Yoshimura 2 collaborations

Takeru Ihara 2 collaborations

Shiyo Enohara 2 collaborations

Yuka Morioka 2 collaborations

Hiroshi Watarai 2 collaborations

Kazuya Iwabuchi 2 collaborations

Taiga Maemoto 2 collaborations

Shunsuke Yamada 2 collaborations

Ari Hashimoto 2 collaborations

Shigeru Hashimoto 2 collaborations

Toyoyuki Ose 2 collaborations

Marie Ishiura 2 collaborations

Kazuna Kikkawa 2 collaborations

Masahiro Fujimuro 2 collaborations

Kyosuke Inui 2 collaborations

Fuki Kobayashi 2 collaborations

Kentaro Fukushima 2 collaborations

Yui Ohgakiuchi 2 collaborations

Yuka Saino 2 collaborations

Ami Sato 2 collaborations

Hiroya Minoguchi 2 collaborations

Tomoaki Ueda 2 collaborations

Masako Kurashige 1 collaboration

Eiichi Morii 1 collaboration

Takuya Fukushima 1 collaboration

Youko Suehiro 1 collaboration

Hiroko Nakatsukasa 1 collaboration

Henyun Shi 1 collaboration

Runa Takahashi 1 collaboration

Haruka Shoji 1 collaboration

Shiho Takei 1 collaboration

Daiki Ito 1 collaboration

Haruka Handa 1 collaboration

Bruce A Witthuhn 1 collaboration

Kiyotaka Ozawa 1 collaboration

Takuya Tsuchiya 1 collaboration

Yasuyo Harada 1 collaboration

Masato Kubo 1 collaboration

Iori Inagaki 1 collaboration

Takuji Kawamoto 1 collaboration

Kyohei Oritani 1 collaboration

Atsushi Kawabata 1 collaboration

Tsubasa Morioka 1 collaboration

Hiroshi Matsubara 1 collaboration

Akio Kamimura 1 collaboration

Shota Nakamura 1 collaboration

Yuki Komori 1 collaboration

Keisuke Tawa 1 collaboration

Naoki Matsumoto 1 collaboration

Kimiya Owashi 1 collaboration

Yuri Hamanaka 1 collaboration

Hiroaki Miyoshi 1 collaboration

Masao Mizuki 1 collaboration

Masao Seto 1 collaboration

Koichi Ohshima 1 collaboration

Shinsuke Yamashita 1 collaboration

Mari Yoshihara 1 collaboration

Yoshihiro Uno 1 collaboration

Tomoji Mashimo 1 collaboration

Yoshiaki Kubota 1 collaboration

Takao Sudo 1 collaboration

Yasuhiro Shingai 1 collaboration

Yukiko Doi 1 collaboration

Takayuki Ozawa 1 collaboration

Ritsuko Nakai 1 collaboration

Shinya Rai 1 collaboration

Hirokazu Tanaka 1 collaboration

Mai Suzuki 1 collaboration

J Luis Espinoza 1 collaboration

Takahiro Kumode 1 collaboration

Toshio Watanabe 1 collaboration

Itaru Matsumura 1 collaboration

Keigo Akuta 1 collaboration

Yukitoshi Takahashi 1 collaboration

Tomohiro Matsumoto 1 collaboration

Nao Koizumi 1 collaboration

Yukie Yamauchi 1 collaboration

Fumiya Okuyama 1 collaboration

Sachie Honda 1 collaboration

Akihiro Mizushima 1 collaboration

Sumihito Togi 1 collaboration