Impaired B cell terminal differentiation in B cell-specific knockout mice of cell death-defying factor anamorsin.

Animals Antigens, CD19 / genetics Apoptosis B-Lymphocytes Cell Differentiation Mice Mice, Knockout Spleen
Anamorsin B cell differentiation Gene knockout Hematopoiesis Iron-sulfur prrotein Lymphocyte

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
07 05 2022
Historique:
received: 21 02 2022
revised: 02 03 2022
accepted: 02 03 2022
pubmed: 9 3 2022
medline: 23 4 2022
entrez: 8 3 2022
Statut: ppublish

Résumé

Anamorsin (AM) is an anti-apoptotic molecule cloned by us as a molecule that confers resistance against apoptosis induced by growth factor deprivation. AM-deficient mice are embryonic lethal, which impedes detailed analyses of the roles of AM in various types of adult cells. To overcome the embryonic lethality, we generated AM conditional knockout (AM

Identifiants

DOI: 10.1016/j.bbrc.2022.03.018 PMID: 35259639
pubmed: 35259639
pii: S0006-291X(22)00337-0
doi: 10.1016/j.bbrc.2022.03.018
pii:
doi:

Substances chimiques

Antigens, CD19 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-6

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflicts of interest associated with this manuscript.

Auteurs

Yuri Hamanaka (Y)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Akira Tanimura (A)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan. Electronic address: atanimura@bldon.med.osaka-u.ac.jp.

Takafumi Yokota (T)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Sachiko Ezoe (S)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Michiko Ichii (M)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Yasuhiro Nagate (Y)

Department of Hematology, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.

Kenji Oritani (K)

Department of Hematology, Graduate School of Medical Sciences, International University of Health and Welfare, 4-3 Kozunomori, Narita, Chiba, 286-8686, Japan.

Yuzuru Kanakura (Y)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan; Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan.

Naoki Hosen (N)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan; Laboratory of Cellular Immunotherapy, World Premier International Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka, 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Hirohiko Shibayama (H)

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan; Department of Hematology, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes B › Antigènes CD19 › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Impaired B cell terminal differentiation in B...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Impaired B cell terminal differentiation in B...